501428-67-7Relevant academic research and scientific papers
Synthesis of substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy
Khose, Goraksha,Shinde, Shailesh,Panmand, Anil,Kulkarni, Ravibhushan,Munot, Yogesh,Bandyopadhyay, Anish,Barawkar, Dinesh,Patil, Santoshkumar N.
supporting information, p. 2671 - 2674 (2014/05/06)
A novel synthetic route to substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylates via C-formylation of glycine ethyl ester hydrochloride is reported. This methodology is simple, robust, and gives good yields of different heterocyclic esters in one or two steps from a common acyclic precursor and is amenable to large scale synthesis.
