76075-07-5Relevant academic research and scientific papers
Novel nonprostanoid prostacyclin (PGI2) mimetics with heterocyclic moiety
Nagao, Yuuki,Takahashi, Kanji,Torisu, Kazuhiko,Kondo, Kigen,Hamanaka, Nobuyuki
, p. 517 - 523 (2007/10/03)
Structural modification of [2-(2-benzhydryloxyiminopentyl)-1,2,3,4-tetrahydro-5-naphthyloxy]acetic acid (4), previously identified as a PGI2 agonist without a PG skeleton, was examined. Conversion of the oxime moiety in 4 to the pyrazole led to [2-(4-benzhydrylpylazoyl)methyl-1,2,3,4-tetrahydro-5-naphthyloxy]acetic acid (34) which strongly inhibited ADP-induced aggregation of human platelets in vitro.
Imidazole derivatives with potential biological activity
Belgodere,Bossio,Parrini,Pepino
, p. 1051 - 1056 (2007/10/02)
A series of 1-substituted imidazole-5-carbohydroxamic acids Ia, Ib and Ie were prepared from the corresponding 5-methoxycarbonyl imidazoles (IX) obtained by a univocal synthesis starting with the reaction of the amines (III) with ethylchloroacetate. On treatment of 4(5)-methoxycarbonyl imidazoles (XI) with alkylar halides (X), on the contrary, mixtures of 1-substituted-4(or 5)-methoxycarbonyl imidazoles were obtained that, when separated by thin-layer chromatography, gave the carbohydroxamic acids Ia, Ib, Id and Ie and IIa→f. The structures of the imidazole derivatives were obtained by means of IR, NMR and UV spectra. On carrying out tests of biological activity on these compounds, it had been found that the 5-carbohydroxamic acids possess, compared to the 4-carbohydroxamic ones, a greater activity. Particularly Ib and Ib-HCl seem fairly active against Klebsiella pneumoniae and Clostridium bifermentans, Ib-HCl against Bacillus subtilis, too.
