501675-34-9

Upstream product

• 829-31-2 3-(4-chlorophenyl)sydnone 
• 141-43-5 ethanolamine 
• 269392-85-0 3-(4-chlorophenyl)-5-methyl-2-oxo-Δ⁴-1,3,4-oxadiazole 

Downstream Products

• 1001077-50-4 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl acetate 
• 1001077-57-1 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate 
• 1430405-39-2 4-(2-(1H-benzo[d][1,2,3]triazol-1-yl)ethyl)-2-(4-chlorophenyl)-5-methyl-2H-1,2,4-triazol-3(4H)-one 
• 1430405-40-5 3-(2-(1-(4-chlorophenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)ethyl)thiazolidine-2,4-dione 
• 1430405-41-6 4-(2-(1H-benzo[d]imidazol-1-yl)ethyl)-2-(4-chlorophenyl)-5-methyl-2H-1,2,4-triazol-3(4H)-one 
• 1430405-42-7 2-(4-chlorophenyl)-5-methyl-4-(2-(4-methylpiperazin-1-yl)ethyl)-2H-1,2,4-triazol-3(4H)-one 
• 1430405-43-8 C₂₁H₁₈ClN₃O₄ 
• 1430405-44-9 2-(4-chlorophenyl)-4-(2-(5-chloroquinolin-8-yloxy)ethyl)-5-methyl-2H-1,2,4-triazol-3(4H)-one 
• 1430405-45-0 2-(4-chlorophenyl)-5-methyl-4-(2-(2-oxo-2H-chromen-4-yloxy)ethyl)-2H-1,2,4-triazol-3(4H)-one 
• 1430405-46-1 2-(4-chlorophenyl)-5-methyl-4-(2-(o-tolyloxy)ethyl)-2H-1,2,4-triazol-3(4H)-one 
• 1430405-47-2 2-(4-chlorophenyl)-5-methyl-4-(2-(p-tolyloxy)ethyl)-2H-1,2,4-triazol-3(4H)-one 
• 1430405-48-3 2-(4-chlorophenyl)-5-methyl-4-(2-(m-tolyloxy)ethyl)-2H-1,2,4-triazol-3(4H)-one 
• 1430405-49-4 2-(4-chlorophenyl)-5-methyl-4-(2-(4-nitrophenoxy)ethyl)-2H-1,2,4-triazol-3(4H)-one 
• 1430405-50-7 4-(2-(4-bromophenoxy)ethyl)-2-(4-chlorophenyl)-5-methyl-2H-1,2,4-triazol-3(4H)-one 

Relevant academic research and scientific papers

Synthesis, characterization and in vitro anticancer evaluation of novel 1,2,4-triazolin-3-one derivatives

A series of novel 2-(4-chlorophenyl)-5-methyl-4-(2-amine/oxy-ethyl)-2,4- dihydro-[1,2,4]triazol-3-one (5a-t) were synthesized and in vitro anticancerous action of the resulting compounds was studied against NCI-60 Human Tumor Cell Line at a single high do

A simple and efficient synthesis of novel N,N′-Bis (1H-pyrrol-1-yl)-1-[2-(2-aryl-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl) ethyl]-1H-1,2,3-triazole-4,5-dicarboxamides

(Chemical Equation Presented) One-pot reaction of 3-aryl-5-methyl-1,3,4- oxadiazolin-2-ones 1a-g with ethanolamine yielded the 4-(2-hydroxyethyl)-2-aryl- 5-methyl-2,4-dihydro-3H-1,2,4-triazolin-3-ones 2a-g which were converted to the azido compounds 6a-g. These azides on 1,3-dipolar cycloaddition with DMAD afforded the dimethyl-1-[2-(2-aryl-5-methyl-3-oxo-1,2,4-triazol-4-yl)ethyl]-1H- 1,2,3-triazol-4,5-dicarboxylates 7a-g which on conversion to bishydrazides 8a-g and further cyclisation with 2,5-hexanedione afforded the title compounds 9a-g. This new short route for the so far unkown bis-(triazolinone-triazole)ethanes involves mild and convergent 1,3-dipolar cycloaddition reaction yielding overall good yields of the products.