269392-85-0Relevant academic research and scientific papers
Synthesis, characterization and in vitro anticancer evaluation of novel 1,2,4-triazolin-3-one derivatives
Kattimani, Pramod P.,Kamble, Ravindra R.,Kariduraganavar, Mahadevappa Y.,Dorababu, Atukuri,Hunnur, Raveendra K.
, p. 232 - 240 (2013/05/21)
A series of novel 2-(4-chlorophenyl)-5-methyl-4-(2-amine/oxy-ethyl)-2,4- dihydro-[1,2,4]triazol-3-one (5a-t) were synthesized and in vitro anticancerous action of the resulting compounds was studied against NCI-60 Human Tumor Cell Line at a single high do
Zinc triflate catalyzed facile synthesis of novel 1,2,4-triazolinone derivatives using 3-Arylsydnone as synthon
Dorababu, Atukuri,Kamble, Ravindra R.,Kattimani, Pramod P.
, p. 510 - 517 (2013/08/23)
A series of novel tetrazoles (4a-k) and thiazolidinones (6a-k) appended to 2-Aryl-1,2,4-triazolin-3-ones were efficiently synthesized from 3-Arylsydnones (1a-k) in excellent yields using Zinc triflate as catalyst.
Facile TICl4-catalyzed synthesis of novel 1,2,4-triazoles appended to thiazoles
Gireesh,Kamble,Hunnur,Taj,Kariduraganavar
scheme or table, p. 877 - 885 (2012/04/04)
The reaction of sydnone-derived 3-aryl-5-methyl-1,3,4-oxadiazol-2(3H)-ones with thiourea and α-bromoacetophenone derivatives in the presence of a catalytic amount of TiCl4 produces 2-aryl-4-(4-aryl-1,3-thiazol-2-yl) -5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-ones. The title compounds were screened for their antibacterial and antifungal activity. The toxicity of the compounds was evaluated in terms of mutagenicity, tumorigenicity, and reproductive effects. The drug-relevant properties (ClogP, drug-likeness, and drug score) were calculated, and the structure-activity relationship was discussed.
Transformation of the sydnone ring into oxadiazolinones. A convenient one-pot synthesis of 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones from 3- arylsydnones and their antimicrobial activity
Mallur, Shanta G.,Badami, Bharati V.
, p. 65 - 67 (2007/10/03)
3-Arylsydnones (Ia-u) have been converted into the corresponding 3-aryl- 5-methyl-1,3,4-oxadiazolin-2-ones (IIIa-u) by a single-step reaction with bromine in acetic anhydride. In the preliminary screening of all these compounds, the halogen-substituted de
Syntheses of α-Haloformylarylhydrazines and Their Self-dimerizations
Kuo, C. N.,Wu, M. H.,Chen, S. P.,Li, T. P.,Huang, C. Y.,Yeh, M. Y.
, p. 849 - 856 (2007/10/03)
α-Haloformylarylhydrazine hydrohalides 1 were prepared through ring opening of 3-aryl-4-halosydnones 7 with hydrohalic acids in EtOAc in moderate yields.Reactions between compounds 1 and primary alcohols gave alkyl 1-arylhydrazinecarboxylates 12 and 14, important intermediates in syntheses of antiinflammatory drugs.Compounds, 16, 4-aryl-2-(arylhydrazin-1-yl)-1,3,4-oxadiazolin-5-ones, and compounds 18, 1,4-diaryl-1,4-dihydro-1,2,4,5-tetrazine-3,6-(2H,5H)-diones, were synthesized by self-dimerization of compounds 1.Compounds 18 were also converted to compounds 17 via intramolecular rearrangement.Structural elucidation and verification of the reaction mechanisms are presented.Key Words 3-Aryl-4-halosydnone; α-Haloformylarylhydrazine hydrohalide; Acid hydrolysis; Self-dimerization; Intramolecular rearrangement.
