5018-54-2Relevant academic research and scientific papers
A method for preparing sulfanilamide multi-Xin derivatives (by machine translation)
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Paragraph 0021, (2017/08/28)
The invention discloses a sulfanilamide multi-Xin derivative I is 4 - (4 - acetyl amino sulfonyl amino) - 5, 6 - dimethoxy pyrimidine preparation method; sulfanilamide multi-Xin derivative I is sulfanilamide multi-Xin acetylation impurity, is sulfanilamide multi-Xin bulk drug or preparation of one of the main impurities; sulfanilamide multi-Xin derivatives I can be used for analysis and measurement of the purity of the sulfanilamide multi-Xin, so as to control the quality of the sulfanilamide multi-Xin. (by machine translation)
The metabolism of four sulphonamides in cows
Nielsen
, p. 1039 - 1045 (2007/10/04)
The metabolism of sulphanilamide, sulphadimidine (4,6 dimethyl 2 sulphanilamido pyrimidine), sulphamethoxazole (5 methyl 3 sulphanilamidoisoxazole) and sulphadoxine (5,6 dimethoxy 4 sulphanilamidopyrimidine) given by intravenous injection has been examined in cows. The sulphonamides were present mainly as unchanged drugs in blood samples collected 2 hr after administration. The sulphonamides were excreted in the milk partly as unchanged drugs and partly as conjugated metabolites whereas only small amounts were excreted as the N4 acetyl derivatives. The unchanged drug and the N4 acetyl derivative were the major constituents in urine samples after administration of sulphanilamide, sulphamethoxazole and sulphadoxine. Besides the unchanged drug, the N4 acetyl derivative and the conjugated metabolites, three further metabolites of sulphadimidine were isolated from urine samples and identified. They were 5 hydroxy 4,6 dimethyl 2 sulphanilamidopyrimidine, 4 hydroxymethyl 6 methyl 2 sulphanilamido pyrimidine and sulphaguanidine.
