502-95-4

Usage

Uses

Used in Pharmaceutical Industry:
Tetrahydro-3,6-pyridazinedione is used as an active pharmaceutical ingredient for its potential therapeutic properties. It is being studied for its ability to act as a neurotransmitter inhibitor, which could have implications for the treatment of various neurological conditions.
Used in Agrochemical Industry:
In the agrochemical sector, Tetrahydro-3,6-pyridazinedione is utilized in the development of new compounds that can enhance crop protection and management strategies.
Used in Material Development:
Tetrahydro-3,6-pyridazinedione is also used in the development of new materials, where its unique structure and properties can contribute to the creation of innovative products.
Used in Research:
Tetrahydro-3,6-pyridazinedione serves as a building block for the synthesis of other organic compounds in research settings, allowing scientists to explore its potential applications and reactions further.

InChI:InChI=1/C4H6N2O2/c7-3-1-2-4(8)6-5-3/h1-2H2,(H,5,7)(H,6,8)

Upstream product

• 123-33-1 Maleic hydrazide 
• 123-33-1 3,6-dihydroxypyridazine 
• 108-30-5 succinic acid anhydride 
• 79785-97-0 hydrazine hydrate 

Downstream Products

• 21827-92-9 1,2-Diacetyl-perhydropyridazindion-3,6 
• 5343-01-1 Perhydro-1,4,6,9-tetraketo-pyridazo<1,2-a>pyridazin 
• 65886-43-3 1,2-dimethyltetrahydropyridazine-3,6-dione 
• 17973-86-3 3,6-dibromopyridazine 
• 113410-90-5 4,5-Bis-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-tetrahydro-pyridazine-3,6-dione 
• 112372-91-5 4,5-dibenzylidenetetrahydro-pyridazine-3,6-dione 
• 112372-91-5 4,5-Bis-[1-phenyl-meth-(Z)-ylidene]-tetrahydro-pyridazine-3,6-dione 

Relevant academic research and scientific papers

Synthesis of fluorous tags for incorporation of reducing sugars into a quantitative microarray platform

Carbohydrate microarrays can map out key interactions of carbohydrates and proteins in a high-throughput manner, but require the inclusion of a range of sugars for their optimal use. Here we present the synthesis and use of a new hydroxylamine-modified fluorous tag that allows the facile incorporation of reducing sugars into a noncovalent fluorous-based microarray after simple purification by fluorous solid-phase extraction (FSPE). The microarray supports quantitative screening against carbohydrate-binding proteins.

The normal coordinate analysis of cyclic succinhydrazide (tetrahydro-3,6-pyridazinedione)

The i.r. spectra of cyclic succinhydrazide and cyclic succinhydrazide-d2 in the solid state have been measured in the region between 4000 and 250 cm-1.The normal coordinate analysis has been performed as a 14-body problem with C2 molecular symmetry.A simple Urey-Bradley force field has been used and the force constants have been refined by the least squares method.The vibrational assignments have been made on the basis of the calculated frequencies and the potential energy distributions.The calculated frequencies in both isotopic species were in good agreement with the observed frequencies.The skeletal streching force constants have been compared with those of glycine anhydride.Consequently, it has been found that in the cyclic succinhydrazide molecule the double bond is delocalized throughout the bonds O=C-N-N-C=O.

One-pot, four-component synthesis of new 3,4,7,8-tetrahydro-3,3-dimethyl-11-aryl-2H-pyridazino[1,2-a]indazole-1,6,9(11H)-triones and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using an acidic ionic liquid N,N-diethyl-N-sulfoethanammonium chloride ([Et3N-SO3H]Cl) as a highly efficient and recyclable catalyst

A rapid and efficient one-pot, four-component protocol for the synthesis of novel 2H-pyridazino[1,2-a]indazole-1,6,9(11H)-triones (6) and 2H-indazolo[2,1-b]phthalazine-1,6,11-triones (7) has been developed using a stable and reusable Br?nsted acidic ionic liquid N,N-diethyl-N-sulfoethanammonium chloride ([Et3N-SO3H]Cl). A range of diverse aldehydes were successfully applied and the corresponding products obtained in good to excellent yields without any by-products.

Green and efficient synthesis of 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydropthalazine-1,4-dione

2-Hydrazinoquinazolin-3H-4-ones 1a,b were reacts with each of the anhydrides, phthalic anhydride 2a, succinic anhydride 2b and maleic anhydride 2c independently in PEG-600 at RT to yield 2-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazineecarbonyl) benzoic acid 3a,b, 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)butanoic acid 3c,d and 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)but-2-enoic acid 3e,f, respectively. 3a, b, 3c,d, 3e,f have been transformed into 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-dione 4a,b, 1-(4-oxo-3,4-dihydroquinazolin-2-yl)piperazine-3,6-dione 4c,d and 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,2-dihydropyridazine-3,6-dione 4e,f, respectively by heating each in PEG-600 at 100°C for 3-3.5 hr in high yields and in high purity, involving a dehydrative ring closure. The final compounds 4a-f have also been prepared alternatively by reacting 1 with 2 in PEG-600 at 100°C for 3.5-4 hr.

Effect of remote trigonal carbons on the kinetics of Bergman cyclization: Synthesis and chemical reactivity of pyridazinedione-based enediynes

The synthesis and chemical reactivity of pyridazinedione-based enediynes (1, 2) are described. Both of these enediynes, namely the dihydro compound 1 and its corresponding tetrahydro analogue 2, were prepared by double N,O-alkylation of the corresponding