502159-95-7

Upstream product

• 623566-49-4 tert-butyl (2-((2R,3S,6S)-6-(iodomethyl)-3-methyltetrahydro-2H-pyran-2-yl)ethoxy)diphenylsilane 
• 623566-48-3 (6S)-(2-hydroxy-ethyl)-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester 
• 623566-58-5 (6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester 
• 623566-59-6 ((2S,5S,6R)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-methyltetrahydro-2H-pyran-2-yl)methanol 
• 623566-55-2 (6S)-[2-(dimethylphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester 
• 623566-47-2 (2S,5S,6S)-6-[2-(dimethylphenylsilyl)vinyl]-5-methyl-5,6-dihydro-2H-pyran-2-carboxylic acid methyl ester 

Downstream Products

• 502160-04-5 1-{(6R)-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(5S)-methyl-tetrahydro-pyran-(2S)-yl}-6-methyl-hept-3-en-2-one 
• 623566-61-0 (6-{5-[6-(2-benzyloxy-6-methyl-hept-3-enyl)-3-methyl-tetrahydro-pyran-2-yl]-4-hydroxy-2-oxo-pentyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)acetic acid tert-butyl ester 
• 623566-50-7 {2-[(2R,3S,6S)-6-((E)-(R)-2-Benzyloxy-6-methyl-hept-3-enyl)-3-methyl-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane 
• 623566-56-3 1-{(6S)-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-yl}-6-methyl-hept-3-en-(2R)-ol 
• 623566-57-4 [(6S)-((2R)-benzyloxy-6-methyl-hept-3-enyl)-(3S)-methyltetrahydro-pyran-(2S)-yl]-ethanol 
• 623566-45-0 [(2R,3S,6S)-6-((2R)-2-benzyloxy-6-methylhept-3-enyl)-3-methyltetrahydropyran-2-yl]acetaldehyde 

Relevant academic research and scientific papers

Enantioselective [4 + 2]-Annulation of Chiral Crotylsilanes: Application to the Synthesis of a C1-C22 Fragment of Leucascandrolide A

(Formula presented). The asymmetric synthesis of a C1-C22 fragment (2) of leucascandrolide A is described. Synthetic highlights include the construction of the C9-C22 pyran fragment using a formal [4 + 2]-annulation of a chiral organosilane. A diastereose