502421-44-5Relevant articles and documents
PROCESS FOR THE PREPARATION OF VALACYCLOVIR
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Page/Page column 13, (2017/09/15)
The present invention relates to an improved process for the preparation of Valacyclovir or pharmaceutically acceptable salts thereof, which comprises reaction of amine -protected Valacyclovir or its salt with deprotecting agent in a continuous flow reactor.
Structure-activity relationships for dipeptide prodrugs of acyclovir: Implications for prodrug design
Santos, Cledir R.,Capela, Rita,Pereira, Claudia S.G.P.,Valente, Emilia,Gouveia, Luis,Pannecouque, Christophe,De Clercq, Erik,Moreira, Rui,Gomes, Paula
experimental part, p. 2339 - 2346 (2009/12/07)
A series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (ACV) were evaluated for their chemical stability, cytotoxicity, and antiviral activity against several strains of Herpes Simplex-1 and -2, vaccinia, vesicular stomatitis, cytom