502434-54-0

Basic information

• Product Name: 1,2-Propanediol, 3-[(2-fluorophenyl)methylamino]-, (2S)-
• CAS NO: 502434-54-0
• Molecular Formula: C10H14FNO2
• Molecular Weight: 199.225
• Mol File: 502434-54-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-Propanediol, 3-[(2-fluorophenyl)methylamino]-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanediol, 3-[(2-fluorophenyl)methylamino]-, (2S)-(502434-54-0)
• EPA Substance Registry System: 1,2-Propanediol, 3-[(2-fluorophenyl)methylamino]-, (2S)-(502434-54-0)

Safety Data

• Hazardous Substances Data: 502434-54-0(Hazardous Substances Data)

Upstream product

• 1978-38-7 2-fluoro-N-methylaniline 
• 57044-25-4 (R)-oxiranemethanol 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 502607-40-1 4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl chloride 
• 502434-61-9 methyl 4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoate 

Relevant articles and documents

PHENYLACETIC ACID COMPOUND

A compound represented by formula (I), wherein R1 represents a hydrogen atom, etc., R2 and R3 each independently represents a hydrogen atom, optionally oxidized C1-4 alkyl group or optionally protected hydroxyl group, or R2 and R3 taken together represent optionally oxidized C2-5 alkylene group, R4 represents an optionally oxidized C1-6 alkyl group, etc., R5 represents an optionally oxidized C1-6 alkyl group, etc., R6 represents an optionally oxidized C1-6 alkyl group, etc., m represents 0 or an integer from 1 to 3, n represents 0 or an integer from 1 to 4, and i represents 0 or an integer from 1 to 7.

INDOLE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT

An indole derivative compound represented by formula (I) (wherein the symbols in the formula are as mentioned in the specification) and a salt thereof Since the compounds represented by formula (I) binds to PGD2 receptors and shows antagonistic activity, they are believed to be useful for prevention and/or treatment of diseases such as allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, systemic mast cell activating disorder, anaphylaxis shock, airway contraction, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis, urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleep disorder) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, autoimmune disease, chronic articular rheumatism, pleuritis, ulcerative colitis and irritable bowel syndrome.

INDOLE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Indole derivatives represented by formula (I) ???wherein all symbols represent the same as that in specification), production methods thereof, and DP receptor antagonist comprising them as active ingredients. Since the compounds of formula (I) binds and antagonizes to DP receptor, they are useful for the prevention and/or treatment against allergic diseases, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis.