502545-54-2

Upstream product

• 22247-58-1 2-(3-hydroxymethyl-2-hydroxy-5-methylbenzyl)-6-hydroxymethyl-4-methylphenol 
• 173736-46-4 2,2'-methylene bis(4-methyl-6-methoxymethylphenol) 
• 50-00-0 formaldehyd 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 3236-63-3 2,2'-methylenebis(4-methylphenol) 
• 100-97-0 hexamethylenetetramine 
• 106-44-5 p-cresol 
• 4383-07-7 2-hydroxymethyl-4-methylphenol 

Downstream Products

• 1422766-61-7 C₄₁H₅₀N₂O₂ 
• 1422766-62-8 C₃₁H₃₀N₂O₂ 
• 1422766-63-9 C₂₉H₂₄Cl₂N₂O₂ 
• 1422766-64-0 C₃₁H₃₀N₂O₄ 
• 1422766-65-1 C₂₅H₃₄N₂O₂ 

Relevant academic research and scientific papers

Synthesis of Monofunctionalized Calix[5]arenes

Seven OH-free and O -permethylated monofunctionalized calix[5]arenes carrying either additional methyl or tert -butyl groups are prepared following fragment condensation protocols. This strategy proves to be superior to previous approaches. Calix[5]arenes with free OH groups all adopt a cone conformation stabilized by a seam of hydrogen bonds at the lower rim. Post-condensation modifications, i.e., methylation of phenolic OH groups or functional group interconversions can also be achieved. Bulky tert -butyl groups are also found to stabilize the cone conformations of O -methylated compounds. These compounds offer versatile functional groups that make these concave molecules interesting building blocks for the synthesis of more sophisticated molecular architectures.

Calixarene and hemicarcerand-like compounds obtained by self-assembly of 3-aminophenylboronic acid and salicylaldehyde derivatives

One-pot synthesis of calixarene and hemicarcerand like compounds can be modulated by use of mono- or bis-salicylaldehyde derivatives respectively, reacting with 3-aminophenylboronic acid. Thus, the first part of this work is focused on the synthesis of calix-like compounds derived from salicylaldehyde units including different substituents on the aromatic moiety. Seven different calix structures are described and their structural analysis has been carried out by spectroscopic techniques. The second part corresponds to the description of bis-salicylaldehyde derivatives, synthesis and reactivity towards the 3-aminophenylboronic acid leading to the formation of hemicarcerand-like compounds. Aliphatic and aromatic chains were inserted as linkers between the two salicylaldehyde units in order to evaluate the influence on the formation of the hemicarcerands compounds. Both, calixarene and hemicarcerand compounds resulted from condensation reactions, wherein the formation of N-B coordination bonds plays a significant role on the macrocyclization process.

METHOD FOR PRODUCING NEW POLYNUCLEAR POLY(FORMYLPHENOL)

Produce the target substance, or a polynuclear poly(formylphenol) expressed by General Formula (2), in an industrial setting with ease and at high purity by causing a polynuclear poly(hydroxymethylphenol) or polynuclear poly(alkoxymethylphenol) to react with hexamethylene tetramine in the presence of an acid and then hydrolyzing the obtained reaction product.