502610-15-3Relevant academic research and scientific papers
Reverse hydroxamate-based selective TACE inhibitors
Kamei, Noriyuki,Tanaka, Tomohiro,Kawai, Kentaro,Miyawaki, Kyosei,Okuyama, Akihiko,Murakami, Yoshiko,Arakawa, Yoshio,Haino, Makoto,Harada, Tatsuhiro,Shimano, Masanao
, p. 2897 - 2900 (2004)
Reverse hydroxamate-based selective TACE inhibitors are described. They have potent TACE inhibitory activities and excellent selectivities against MMP-1, 2, 3, 8, 9, 13, 14, and 17. One representative compound, 18 has demonstrated an excellent oral inhibitory activity of the lipopolysaccharide (LPS)-stimulated TNF-α production in rats.
