502626-21-3

Basic information

• Product Name: C₄₇H₅₂Cl₃NO₁₅
• Synonyms: C₄₇H₅₂Cl₃NO₁₅
• CAS NO: 502626-21-3
• Molecular Weight: 977.287
• Mol File: 502626-21-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₇H₅₂Cl₃NO₁₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₇H₅₂Cl₃NO₁₅(502626-21-3)
• EPA Substance Registry System: C₄₇H₅₂Cl₃NO₁₅(502626-21-3)

Safety Data

• Hazardous Substances Data: 502626-21-3(Hazardous Substances Data)

Upstream product

• 204124-97-0 7-trichloroacetylbaccatin III 
• 204125-01-9 C₄₅H₄₈Cl₅NO₁₄ 
• 35660-94-7 (E)-2-methylbut-2-enoyl chloride 
• 261728-77-2 7-trichloroacetyl-3'-debenzoylpaclitaxel 

Downstream Products

• 71610-00-9 cephalomannine 

Relevant articles and documents

Structure-activity relationship study at the 3'-N-position of paclitaxel: synthesis and biological evaluation of 3'-N-acyl-paclitaxel analogues.

A series of 3'-N-acyl-paclitaxel analogues 1a-v were synthesized and their cytotoxicities in vitro against several human tumor cell lines examined. It has been shown that distinct correlation between activity and N-acyl-substituent. The appropriate size of N-acyl group was indispensable for cytotoxicity, and moreover, the presence of beta-substituted conjugated double and triple bond to N-carbonyl generally resulted in increase of cytotoxicities.