5028-15-9

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYL-4-(3-NITRO-2-PYRIDINYL)PIPERAZINE is used as a chemical intermediate for the synthesis of various drugs, leveraging its unique structure to contribute to the development of new therapeutic agents.
Used in Cancer Treatment Research:
In the field of oncology, 1-METHYL-4-(3-NITRO-2-PYRIDINYL)PIPERAZINE is explored as a potential therapeutic agent for the treatment of various types of cancer. Its specific molecular properties may allow it to target and affect cancer cells, offering a new avenue for cancer treatment.
Used in Neurological Disorder Research:
1-METHYL-4-(3-NITRO-2-PYRIDINYL)PIPERAZINE is also being investigated for its potential applications in the treatment of neurological disorders. Its capacity to interact with specific biological targets makes it a candidate for developing drugs aimed at managing or treating such conditions.

InChI:InChI=1/C10H14N4O2/c1-12-5-7-13(8-6-12)10-9(14(15)16)3-2-4-11-10/h2-4H,5-8H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 5028-17-1 2-(4-methylpiperazin-1-yl)pyridin-3-amine 

Relevant academic research and scientific papers

METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

lndazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole-3- carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR

The present invention relates to novel derivatives, that are compounds of Formula (I), wherein R1, R2, R3, R14, X, Y, n and m are defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and methods using said compounds in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, antagonists of 5-HT1B are useful.