50289-13-9

Usage

Uses

Used in Pharmaceutical Synthesis:
2H-Pyran-4-carboxylic acid, tetrahydro-4-hydroxy-(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of novel drug molecules. Its heterocyclic nature and functional groups facilitate the creation of diverse chemical entities with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2H-Pyran-4-carboxylic acid, tetrahydro-4-hydroxy-(9CI) is employed as a building block for the production of agrochemicals, such as pesticides and herbicides. Its structural features allow for the design of compounds that can effectively target and control pests and weeds, thereby enhancing crop protection and yield.
Used in Medicinal Chemistry and Drug Discovery:
2H-Pyran-4-carboxylic acid, tetrahydro-4-hydroxy-(9CI) is utilized as a structural component in medicinal chemistry for its potential to contribute to the discovery of new drugs. Its heterocyclic framework and functional groups can be modified to explore various chemical spaces, leading to the identification of bioactive molecules with therapeutic potential.
Further Research:
Due to the compound's structural properties and potential applications, ongoing research is essential to uncover its full potential in various fields. This includes exploring its use in drug delivery systems, targeting specific diseases, and enhancing the efficacy and safety of existing pharmaceuticals and agrochemicals.

Upstream product

• 112799-02-7 4-Trimethylsilanyloxy-tetrahydro-pyran-4-carbonitrile 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 773837-37-9 sodium cyanide 
• 50289-10-6 4-hydroxy-tetrahydropyran-4-carbonitrile 

Downstream Products

• 175982-83-9 4-Methoxy-tetrahydro-pyran-4-carboxylic acid methyl ester 
• 115996-72-0 4-hydroxytetrahydro-2H-pyran-4-carboxylic acid methyl ester 
• 121-44-8 triethylamine 
• 1219005-71-6 benzyl 4-hydroxytetrahydro-2H-pyran-4-carboxylate 

Relevant academic research and scientific papers

Anesthetic compounds and related methods of use

Provided herein are compounds according to formula (I): Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.

Bradykinin B1 receptor antagonists: An α-hydroxy amide with an improved metabolism profile

A series of carbo- and heterocyclic α-hydroxy amide-derived bradykinin B1 antagonists was prepared and evaluated. A 4,4-difluorocyclohexyl α-hydroxy amide was incorporated along with a 2-methyl tetrazole in lieu of an oxadiazole to afford a suitable compound with good pharmacokinetic properties, CNS penetration, and clearance by multiple metabolic pathways.

Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1

2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.

Inhibitors of leukotriene B4. Synthesis and SAR of new β-enaminoester open-chain analogues of Zeneca ZD2138

A series of methoxy tetrahydropyranyl β-enaminoester has been discovered as inhibitors of LTB4 production. These are unusual open chain analogues of Zeneca ZD2138, the highly potent orally active 5-LO inhibitor under development for the treatment of asthma and rheumatoid arthritis. In vitro, compound 1a inhibited LTB4 formation in human whole blood with an IC50 of 0.04 μM. In inflamed exudate in the rat 1a inhibited formation of LTB4 with an oral ED50 3h after dosing of 3.0 mg/kg.