50290-20-5

Usage

Type of compound

A derivative of quinolinone

Usage

Building block for the synthesis of various pharmaceutical drugs

Unique property

The acetyl group attached to the quinolinone ring

Potential pharmacological activities

Anti-inflammatory and antitumor effects

Utilization

Intermediate in the manufacturing of various fine chemicals and active pharmaceutical ingredients

Versatility

Diverse uses in the pharmaceutical and chemical industries

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 529-23-7 o-aminobenzaldehyde 
• 2749-59-9 1,3-dimethyl-5-pyrazolone 

Downstream Products

• 488816-08-6 2-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-ylaminocarbonyl]-benzoic acid 

Relevant academic research and scientific papers

Synthesis of 2-Quinolinones through Palladium(II) Acetate Catalyzed Cyclization of N -(2-Formylaryl)alkynamides

A Pd(OAc)2-catalyzed cyclization of N-(2-formylaryl)alkynamides initiated by the oxypalladation of alkynes was developed. The method provides a new approach for the efficient and atom-economical synthesis of 2-quinolinone derivatives.

Friedlaender Condensation of 1H-Pyrazolin-5-ones with o-Aminobenzaldehydes. Synthesis of 1H-Pyrazoloquinolines

All the possible 1- and 3-monomethyl, monophenyl, dimethyl, diphenyl, and methylphenyl-1H-pyrazolin-5-ones have been condensed with o-aminobenzaldehyde.In some cases (but not all) 1-H-pyrazoloquinolines (10) are formed together with a variety of other products.The balance between formation of hydrazone 11 and the ring-closed 10 is discussed, as is the formation of other products obtained in these condensations.