502935-47-9

Basic information

• Product Name: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
• Synonyms: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID;2,4-DIPHENYLTHIAZOLE-5-CARBOXYLIC ACID;2,4-Diphenyl-1,3-thiazole-5-carboxylic acid 97%;2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC
• CAS NO: 502935-47-9
• Molecular Formula: C₁₆H₁₁NO₂S
• Molecular Weight: 281.33
• Product Categories: pharmacetical
• Mol File: 502935-47-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 212 °C
• Boiling Point: 484.1 °C at 760 mmHg
• Flash Point: 246.6 °C
• Appearance: /
• Density: 1.307 g/cm³
• Vapor Pressure: 3.49E-10mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility: DMSO (Slightly, Sonicated), Methanol (Very Slightly, Heated, Sonicated)
• CAS DataBase Reference: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID(502935-47-9)
• EPA Substance Registry System: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID(502935-47-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 502935-47-9(Hazardous Substances Data)

Usage

Uses

2,4-diphenylthiazole-5-carboxylic acid is used in preparation of FASN inhibitors useful for treatment of cancer and other diseases.

InChI:InChI=1/C16H11NO2S/c18-16(19)14-13(11-7-3-1-4-8-11)17-15(20-14)12-9-5-2-6-10-12/h1-10H,(H,18,19)

Upstream product

• 614-20-0 3-oxo-3-phenylpropionic acid 
• 81447-37-2 ethyl 3-oxo-3-phenyl-2-(tosyloxy)propanoate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 402567-86-6 ethyl 2,4-diphenylthiazole-5-carboxylate 

Downstream Products

• 1253298-97-3 (S)-2,4-diphenyl-N-[(tetrahydrofuran-2-yl)methyl]thiazole-5-carboxamide 
• 1253298-98-4 (R)-2,4-diphenyl-N-[(tetrahydrofuran-2-yl)methyl]thiazole-5-carboxamide 
• 1253299-00-1 N-[(5-methylfuran-2-yl)methyl]-2,4-diphenylthiazole-5-carboxamide 
• 1253299-01-2 N-[(3-methylisoxazol-5-yl)methyl]-2,4-diphenylthiazole-5-carboxamide 
• 1041436-47-8 2,4-diphenyl-N-(thiophen-2-ylmethyl)thiazole-5-carboxamide 
• 1014305-33-9 2,4-diphenyl-N-[(tetrahydrofuran-2-yl)methyl]thiazole-5-carboxamide 
• 502935-48-0 2,4-diphenyl-thiazole-5-carboxylic acid methoxy-amide 
• 857284-13-0 2,4-diphenylthiazole-5-carbonyl chloride 

Relevant articles and documents

Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004

New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

A general and efficient PIFA mediated synthesis of heterocycle-fused quinolinone derivatives

A new application of the hypervalent iodine reagent phenyliodine(III)bis(trifluoroacetate) (PIFA) has been developed for the construction of a series of N, O, S-containing heterocycle-fused quinolinone derivatives in a general and efficient way. An altern