502935-47-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Diphenyl-1,3-thiazole-5-carboxylic acid is used as a key intermediate in the synthesis of FASN (Fatty Acid Synthase) inhibitors for the treatment of cancer and other diseases. These inhibitors target the enzyme responsible for the synthesis of fatty acids, which is often overexpressed in cancer cells, leading to uncontrolled cell growth and proliferation. By inhibiting FASN, these compounds can potentially slow down or stop the growth of cancer cells, making them a valuable tool in the development of novel cancer therapies.

InChI:InChI=1/C16H11NO2S/c18-16(19)14-13(11-7-3-1-4-8-11)17-15(20-14)12-9-5-2-6-10-12/h1-10H,(H,18,19)

Upstream product

• 402567-86-6 ethyl 2,4-diphenylthiazole-5-carboxylate 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 81447-37-2 ethyl 3-oxo-3-phenyl-2-(tosyloxy)propanoate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 857284-13-0 2,4-diphenylthiazole-5-carbonyl chloride 
• 1014305-33-9 2,4-diphenyl-N-[(tetrahydrofuran-2-yl)methyl]thiazole-5-carboxamide 
• 1041436-47-8 2,4-diphenyl-N-(thiophen-2-ylmethyl)thiazole-5-carboxamide 
• 1253299-01-2 N-[(3-methylisoxazol-5-yl)methyl]-2,4-diphenylthiazole-5-carboxamide 
• 1253299-00-1 N-[(5-methylfuran-2-yl)methyl]-2,4-diphenylthiazole-5-carboxamide 
• 1253298-98-4 (R)-2,4-diphenyl-N-[(tetrahydrofuran-2-yl)methyl]thiazole-5-carboxamide 
• 1253298-97-3 (S)-2,4-diphenyl-N-[(tetrahydrofuran-2-yl)methyl]thiazole-5-carboxamide 
• 502935-48-0 2,4-diphenyl-thiazole-5-carboxylic acid methoxy-amide 

Relevant academic research and scientific papers

Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004

New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

A general and efficient PIFA mediated synthesis of heterocycle-fused quinolinone derivatives

A new application of the hypervalent iodine reagent phenyliodine(III)bis(trifluoroacetate) (PIFA) has been developed for the construction of a series of N, O, S-containing heterocycle-fused quinolinone derivatives in a general and efficient way. An altern