502960-94-3Relevant academic research and scientific papers
A facile microwave assisted green chemical synthesis of novel piperidino 2-thioxoimidazolidin-4-ones and their in vitro microbiological evaluation
Kanagarajan,Thanusu,Gopalakrishnan
, p. 67 - 77 (2011/10/17)
A series of novel hybrid heterocyclic compounds, 3-(3-alkyl-2,6- diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones were synthesised and a comparative study was also carried out under microwave irradiation. The synthesised compounds were characterised by their melting points, elemental analysis, MS, FT-IR, one-dimensional NMR (1H, D2O exchanged 1H and 13C), two dimensional HOMOCOSY and NOESY spectroscopic data. All the synthesised title compounds were screened for their in vitro antibacterial and antifungal activity against clinically isolated strains namely B. subtilis, M. luteus, S. typhii, S. paratyphii B, S. felxneri, P. vulgaris, A. niger, Mucor, Rhizopus and M. gypsuem and the results were discussed.
Synthesis and microbiological evaluation of novel [N-acetyl-2,6- diarylpiperidin-4-yl]-5-spiro-4-acetyl-2-(acetylamino)-Δ2-1,3, 4-thiadiazolines
Balasubramanian,Ramalingan,Aridoss,Parthiban,Kabilan
, p. 297 - 311 (2007/10/03)
Some novel spiropiperidinyl thiadiazolines have been synthesized and their bacterial activity against Streptococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Klepsiella pneumoniae and antifungal activity against Cryptococcus neoformans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus were evaluated. Compound 23 exhibited potent antibacterial activity in vitro against Klepsiella pneumoniae while compound 24 exerted potent antifungal activity in vitro against Cryptococcus neoformans. Birkhaeuser Boston 2004.
