50297-40-0

Basic information

• Product Name: CHEMBRDG-BB 6018839
• Synonyms: CHEMBRDG-BB 6018839;3-CHLORO-N-(3-HYDROXYPHENYL)PROPANAMIDE;3-chloro-N-(3-hydroxyphenyl)propanamide(SALTDATA: FREE);3-Chloro-N-(3-hydroxy-phenyl)-propionamide
• CAS NO: 50297-40-0
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.63
• Mol File: 50297-40-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 429.2°C at 760 mmHg
• Flash Point: 213.4°C
• Appearance: /
• Density: 1.341g/cm³
• Vapor Pressure: 5.68E-08mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• Solubility: Dmso (Slightly), Methanol (Slightly)
• PKA: 9.52±0.10(Predicted)
• CAS DataBase Reference: CHEMBRDG-BB 6018839(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 6018839(50297-40-0)
• EPA Substance Registry System: CHEMBRDG-BB 6018839(50297-40-0)

Safety Data

• Hazardous Substances Data: 50297-40-0(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 6018839 is a chemical compound described as a small molecule inhibitor. It is currently being researched for its potential therapeutic applications in various areas of medicine. The compound is known for its ability to interact with specific biological targets, and it is being studied for its potential to modulate or block certain biological processes. The exact properties and mechanism of action of CHEMBRDG-BB 6018839 are still being investigated, but early research suggests that it may have potential as a drug candidate for the treatment of certain diseases or conditions.

InChI:InChI=1/C9H10ClNO2/c10-5-4-9(13)11-7-2-1-3-8(12)6-7/h1-3,6,12H,4-5H2,(H,11,13)

Upstream product

• 625-36-5 2-chloropropionyl chloride 
• 591-27-5 m-Hydroxyaniline 

Downstream Products

• 22246-18-0 7-hydroxy-3,4-dihydro-2-(1H)-quinolinone 
• 1227513-30-5 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-hydroxyphenyl)propanamide 
• 129722-34-5 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone 
• 129722-12-9 aripiprazole 
• 913611-97-9 Brexpiprazole 
• 913613-82-8 7-(4-chlorobutoxy)quinoline-2(1H)-one 
• 70500-72-0 7-hydroxy-1H-quinolin-2-one 
• 1444512-66-6 sodium hydrogen [N-(3-hydroxyphenyl)carbamoyl]ethylphosphonate 
• 1444512-19-9 [N-(3-hydroxyphenyl)carbamoyl]ethylphosphonic acid 
• 1444511-73-2 diethyl 2-[N-(3-hydroxyphenyl)carbamoyl]ethylphosphonate 

Relevant articles and documents

Preparation method of brexpiprazole intermediate 7-hydroxy-1H-quinoline-2-ketone

The invention belongs to the field of chemical engineering, and particularly relates to a preparation method of a brexpiprazole intermediate 7-hydroxy-1H-quinoline-2-ketone. According to the novel method for preparing the 7-hydroxy-1H-quinoline-2-ketone, DDQ is replaced with palladium on carbon, the obtained product is high in yield, few in impurity and easy to operate, the catalyst can be recycled, a target compound is synthesized through direct catalytic dehydrogenation, and the method has green atom economy and is suitable for industrial production.

Method for synthesizing aripiprazole

The invention discloses a method for synthesizing aripiprazole. The method comprises making 4-halogenated-3-nitrophenol react with an ethylenation reagent under palladium catalysis conditions to obtain 3-nitro-4-vinylphenol; making the 3-nitro-4-vinylphenol and 1,4-dihalogenated butane reacting with alkali to obtain 4-(4-halobutoxy)-2-nitro-1-styrene; making the 4-(4-halobutoxy)-2-nitro-1-styreneand 1-(2,3-dichlorophenyl)piperazine salt reacting with the alkali to obtain 1-(2,3-dichlorophenyl)-4-(4-(3-nitro-4-vinylphenoxy)butyl)piperazine; making the 1-(2,3-dichlorophenyl)-4-(4-(3-nitro-4-vinylphenoxy)butyl)piperazine reacting with CO to form the aripiprazole. The method for synthesizing the aripiprazole has the total yield of up to 77% and is simple in post treatment.

Synthesis and antimalarial activity of N-benzylated (N-arylcarbamoyl)alkylphosphonic acid derivatives

A series of novel and readily accessible N-benzylated (N-arylcarbamoyl)alkylphosphonate esters and related compounds have been prepared as potential antimalarial agents. Bioassays reveal that some of these compounds exhibit promising activity against Plasmodium falciparum, and exhibit no significant growth inhibition of HeLa cells.