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2,2-bis(1H-indol-3-yl)propane, also known as BIP, is a chemical compound belonging to the bis-indole family with the molecular formula C20H18N2. It is characterized by its electron-rich nature and unique structure featuring two indole rings connected by a three-carbon bridge. This structure endows BIP with the ability to act as a chelating agent in coordination chemistry and participate in a wide range of chemical reactions, making it a versatile ligand in metal-catalyzed reactions and a promising candidate for the synthesis of organic compounds and pharmaceuticals.

5030-90-0

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5030-90-0 Usage

Uses

Used in Organic and Inorganic Chemistry:
2,2-bis(1H-indol-3-yl)propane is used as a ligand in metal-catalyzed reactions for its electron-rich nature and ability to form complex coordination complexes with various metals. This application is crucial in advancing the field of organic and inorganic chemistry by enabling the development of new synthetic pathways and the discovery of novel compounds.
Used in Pharmaceutical Synthesis:
BIP is used as a building block in the synthesis of pharmaceuticals due to its unique structure and reactivity. Its potential application in the development of new drugs is currently being explored, leveraging its ability to participate in diverse chemical reactions and form stable complexes with metal ions, which can be beneficial for the design of innovative therapeutic agents.
Used in Coordination Chemistry:
2,2-bis(1H-indol-3-yl)propane is used as a chelating agent in coordination chemistry for its ability to form stable complexes with metal ions. This application is significant in the study of metal complexes and their properties, as well as in the development of new materials with potential applications in various fields, such as catalysis, sensing, and energy storage.

Check Digit Verification of cas no

The CAS Registry Mumber 5030-90-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,3 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5030-90:
(6*5)+(5*0)+(4*3)+(3*0)+(2*9)+(1*0)=60
60 % 10 = 0
So 5030-90-0 is a valid CAS Registry Number.

5030-90-0Relevant academic research and scientific papers

Nickel-catalyzed C3-alkylation of indoles with alcohols: Via a borrowing hydrogen strategy

Hu, Miao,Jiang, Yong,Sun, Nan,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan,Jin, Liqun

, p. 10057 - 10062 (2021/06/15)

An efficient method for the Ni-catalyzed C3-alkylation of indoles using readily available alcohols as the alkylating reagents has been developed. The alkylation was addressed with an air and moisture-stable binuclear nickel complex ligated by tetrahydroquinolin-8-one as the effective pre-catalyst. The newly developed transformation could accommodate a broad substrate scope including primary/secondary benzylic and aliphatic alcohols and substituted indoles. Mechanistic studies suggested that the reaction proceeds through a borrowing hydrogen pathway.

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