503020-90-4Relevant academic research and scientific papers
Determination of the lipophilicity of some new derivatives of thiosemicarbazide and 1,2,4-triazoline-5-thione with potential antituberculosis activity
Pitucha, Monika,Polak, Beata,Swatko-Ossor, Marta,Popiolek, Lukasz,Ginalskac, Grazyna
experimental part, p. 299 - 306 (2011/08/07)
The chromatographic behavior of newly obtained derivatives of thiosemicarbazide and 1,2,4-triazoline-5-thione was determined. The lipophilicity was confirmed by the use of the Reversed Phase Thin-Layer Chromatography (RP-TLC) method. For both groups of solutes the lipophilicity depended on the substituents. All obtained compounds were tested for their antimycotic activity. The strongest antituberculosis activity was observed for 4-(2-iodophenyl)-1-(pyridine-4-ylacetyl)thiosemicarbazide 4 and 4-phenyl-3-(pyridine-4-ylmethyl)-1,2,4-triazoline-5-thione 27.
