682745-47-7

Upstream product

• 158144-17-3 (1-methyl-pyrrol-2-yl)acetic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 
• 503020-90-4 1-[(1-methylpyrrol-2-yl)acetyl]-4-phenylthiosemicarbazide 

Relevant academic research and scientific papers

Determination of the lipophilicity of some new derivatives of thiosemicarbazide and 1,2,4-triazoline-5-thione with potential antituberculosis activity

The chromatographic behavior of newly obtained derivatives of thiosemicarbazide and 1,2,4-triazoline-5-thione was determined. The lipophilicity was confirmed by the use of the Reversed Phase Thin-Layer Chromatography (RP-TLC) method. For both groups of solutes the lipophilicity depended on the substituents. All obtained compounds were tested for their antimycotic activity. The strongest antituberculosis activity was observed for 4-(2-iodophenyl)-1-(pyridine-4-ylacetyl)thiosemicarbazide 4 and 4-phenyl-3-(pyridine-4-ylmethyl)-1,2,4-triazoline-5-thione 27.