503040-04-8

Basic information

• Product Name: Benzamide, N-(2-aminophenyl)-4-(4-morpholinyl)-
• Synonyms: N-(2-aminophenyl)-4-morpholinobenzamide
• CAS NO: 503040-04-8
• Molecular Formula: C17H19N3O2
• Molecular Weight: 297.357
• Mol File: 503040-04-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(2-aminophenyl)-4-(4-morpholinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(2-aminophenyl)-4-(4-morpholinyl)-(503040-04-8)
• EPA Substance Registry System: Benzamide, N-(2-aminophenyl)-4-(4-morpholinyl)-(503040-04-8)

Safety Data

• Hazardous Substances Data: 503040-04-8(Hazardous Substances Data)

Upstream product

• 1030830-17-1 C₂₂H₂₇N₃O₄ 

Relevant articles and documents

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors

A lead benzamide, 3, was identified as a potent and low molecular weight histone deacetylase (HDAC) inhibitor. Optimization led to 16d, demonstrating an excellent balance of efficacy and non-efficacy properties, along with very desirable in vivo DMPK. The

Inhibitors of histone deacetylase

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS

The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R1 is a group such as hydroxy, halo, trifluoromethyl and cyano; R2 is halo and n is 0-2; and each R4 is a group such as hydroxy, halo, trifluromethyl and cyano; p is 0-4; and R3 is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by histone deacetylase