1030830-17-1Relevant articles and documents
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors
Andrews, David M.,Stokes, Elaine S.E.,Carr, Greg R.,Matusiak, Zbigniew S.,Roberts, Craig A.,Waring, Michael J.,Brady, Madeleine C.,Chresta, Christine M.,East, Simon J.
, p. 2580 - 2584 (2008/12/21)
A lead benzamide, 3, was identified as a potent and low molecular weight histone deacetylase (HDAC) inhibitor. Optimization led to 16d, demonstrating an excellent balance of efficacy and non-efficacy properties, along with very desirable in vivo DMPK. The
