503071-72-5Relevant academic research and scientific papers
Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-α production
Clark, Michael P.,Laughlin, Steven K.,Laufersweiler, Matthew J.,Bookland, Roger G.,Brugel, Todd A.,Golebiowski, Adam,Sabat, Mark P.,Townes, Jennifer A.,VanRens, John C.,Djung, Jane F.,Natchus, Michael G.,De, Biswanath,Hsieh, Lily C.,Xu, Susan C.,Walter, Rick L.,Mekel, Marlene J.,Heitmeyer, Sandra A.,Brown, Kimberly K.,Juergens, Karen,Taiwo, Yetunde O.,Janusz, Michael J.
, p. 2724 - 2727 (2007/10/03)
2-Aryl-3-pyrimidinyl based tumor necrosis factor-α (TNF-α) inhibitors, which contain a novel bicyclic pyrazolone core, are described. Many showed low-nanomolar activity against lipopolysaccharide-induced TNF-α production in monocytic cells. Secondary scre
