503114-34-9Relevant academic research and scientific papers
The application of vinylogous iminium salt derivatives to the synthesis of Ningalin B hexamethyl ether
Gupton, John T.,Clough, Stuart C.,Miller, Robert B.,Lukens, John R.,Henry, Charlotte A.,Kanters, René P. F.,Sikorski, James A.
, p. 207 - 215 (2003)
A vinylogous iminium salt derivative has been used to prepare a 2,3,4-trisubstituted pyrrole synthon in a regioselective, efficient and convenient manner. This pyrrole synthon was subsequently converted to the multidrug-resistant (MDR) reversal agent, Ningalin B hexamethyl ether, via alkylation, hydrolysis and oxidative lactonization steps. This methodology provides an alternative pathway to this important class of pyrrole containing marine natural products.
