503114-37-2Relevant academic research and scientific papers
The application of vinylogous iminium salt derivatives to efficient formal syntheses of the marine alkaloids lamellarin G trimethyl ether and ningalin B
Gupton, John T.,Giglio, Benjamin C.,Eaton, James E.,Rieck, Elizabeth A.,Smith, Kristin L.,Keough, Matthew J.,Barelli, Peter J.,Firich, Lauren T.,Hempel, Jonathan E.,Smith, Timothy M.,Kanters, Rene P.F.
experimental part, p. 4283 - 4292 (2009/10/17)
Studies directed at the synthesis of lamellarin G trimethyl ether and ningalin B via vinylogous iminium salt derivatives are described. The successful strategy relies on the formation of a 2,4-disubstituted pyrrole or a 1,2,3,4-tetrasubstituted pyrrole fr
The application of vinylogous iminium salt derivatives to the synthesis of Ningalin B hexamethyl ether
Gupton, John T.,Clough, Stuart C.,Miller, Robert B.,Lukens, John R.,Henry, Charlotte A.,Kanters, René P. F.,Sikorski, James A.
, p. 207 - 215 (2007/10/03)
A vinylogous iminium salt derivative has been used to prepare a 2,3,4-trisubstituted pyrrole synthon in a regioselective, efficient and convenient manner. This pyrrole synthon was subsequently converted to the multidrug-resistant (MDR) reversal agent, Ningalin B hexamethyl ether, via alkylation, hydrolysis and oxidative lactonization steps. This methodology provides an alternative pathway to this important class of pyrrole containing marine natural products.
