503168-22-7 Usage
Uses
Used in Pharmaceutical Industry:
2H-Pyran-3-carboxylic acid, 4-aminotetrahydro, methylester, (3R,4R)-(9CI) is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups contribute to the development of new drugs with specific therapeutic properties.
Used in Drug Development:
2H-Pyran-3-carboxylicacid,4-aminotetrahydro-,methylester,(3R,4R)-(9CI) serves as a building block in the creation of novel medicinal entities, potentially leading to advancements in the treatment of various diseases and conditions. Its chiral centers and specific stereochemistry may offer unique opportunities for the design of enantioselective drugs, which can exhibit improved efficacy and reduced side effects compared to their racemic counterparts.
Used in Medicinal Chemistry Research:
2H-Pyran-3-carboxylic acid, 4-aminotetrahydro, methylester, (3R,4R)-(9CI) is employed in the field of medicinal chemistry for the exploration of structure-activity relationships (SAR). Understanding how variations in the molecular structure affect biological activity can guide the optimization of drug candidates and the discovery of more potent and selective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 503168-22-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,3,1,6 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 503168-22:
(8*5)+(7*0)+(6*3)+(5*1)+(4*6)+(3*8)+(2*2)+(1*2)=117
117 % 10 = 7
So 503168-22-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO3/c1-10-7(9)5-4-11-3-2-6(5)8/h5-6H,2-4,8H2,1H3/t5-,6+/m0/s1
503168-22-7Relevant academic research and scientific papers
Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Duan, James J.-W.,Chen, Lihua,Lu, Zhonghui,Xue, Chu-Biao,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Wasserman, Zelda R.,Vaddi, Krishna,Christ, David D.,Trzaskos, James M.,Newton, Robert C.,Decicco, Carl P.
, p. 241 - 246 (2008/09/18)
β-Benzamido hydroxamic acids were discovered as potent TACE inhibitors. A computer model was constructed to help understanding the binding activities and guiding SAR study. SAR optimization led to the discovery of compound 30 which met all in vitro and in
