503174-38-7

Upstream product

• 104115-64-2 2-bromo-7-methyl-1,2,3,4-tetrahydronapthalin-1-one 
• 16188-55-9 2-(4-(methylthio)phenyl)acetic acid 
• 562069-25-4 7-methyl-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl-2-(4-methylsulfanylphenyl)acetate 

Relevant academic research and scientific papers

Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors

A number of naphthofuranones were synthesized and tested for COX-1 and COX-2 inhibition. Few of them were identified as selective COX-2 inhibitors. Structure-activity relationship studies within the series are discussed.

A simple and rapid entry to 5-alkyl (aryl)-5-hydroxy-3,4-diarylfuranones and 3a-hydroxy-1-aryl-2,3a,4,5-tetrahydronaphthofuranones via a tandem esterification and oxidative cyclization process

A synthesis of 5-hydroxy-3,4-diarylfuranones and related derivatives is accomplished by the reaction of arylacetic acid with α-bromoketone in the presence of base and atmospheric oxygen. A variety of compounds were synthesized in good to excellent yield and many are of potential biological interest.