503183-77-5Relevant academic research and scientific papers
Catalytic asymmetric synthesis of (S)-oxybutynin and a versatile intermediate for antimuscarinic agents
Masumoto, Shuji,Suzuki, Masato,Kanai, Motomu,Shibasaki, Masakatsu
, p. 10497 - 10504 (2004)
A practical synthesis of (S)-oxybutynin, a muscarinic receptor antagonist, using catalytic enantioselective cyanosilylation of cyclohexyl phenyl ketone (9a) as a key step is described. The key reaction proceeded with 94% ee using 1 mol% of Gd-1 catalyst,
Method of producing oxybutynin and its derivatives
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Page 4, (2010/02/05)
An oxybutynin and its derivatives are produced by reacting a phenylketone with a silylcyanide in the presence of a specified asymmetric catalyst to obtain a siloxynitrile, and then reacting the siloxynitrile with a reducing agent and oxidizing the resulting aldehyde, or subjecting the siloxynitrile to a hydrolysis.
A practical synthesis of (S)-oxybutynin
Masumoto, Shuji,Suzuki, Masato,Kanai, Motomu,Shibasaki, Masakatsu
, p. 8647 - 8651 (2007/10/03)
(S)-Oxybutynin, an important drug acting as muscarinic receptor antagonist, was practically synthesized using catalytic enantioselective cyanosilylation of cyclohexyl phenyl ketone (6a) as a key step. Cyanohydrin 7a with 94% ee was obtained with 1 mol% of
