503186-64-9

Upstream product

• 503186-54-7 Fmoc-2,6-dimethyl-(L)-Tyr(tBu)-OMe 
• 503186-53-6 Fmoc-2,6-dimethyl-(L)-Tyr-OMe 
• 137650-16-9 N-<(1,1-dimethylethoxy)carbonyl>-O-(1,1-dimethylethyl)-2,6-dimethyl-L-tyrosine methyl ester 
• 137650-17-0 1,1-dimethylethyl <2-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-1(S)-formylethyl>carbamate 
• 479495-61-9 2-benzyl-3-hydroxy-pent-4-enethioic acid S-benzyl ester 
• 503186-55-8 [1-(4-tert-butoxy-2,6-dimethyl-benzyl)-2-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester 

Downstream Products

• 503186-65-0 2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enethioic acid S-benzyl ester 
• 503186-52-5 2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-non-4-enoic acid 
• 503186-57-0 2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enoic acid 

Relevant academic research and scientific papers

2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: Highly potent, selective, non-peptidic μ opioid receptor agonists

We recently reported the use of an exhaustively stereodiversified library based on endomorphin-2 (1) to discover μ opioid receptor (MOR) ligands of type 2-4. Here, we report the synthesis and evaluation of 2,6-dimethyltyrosine analogues 5-10. These analog