503292-41-9Relevant academic research and scientific papers
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain
Dominguez, Esteban,Iyengar, Smriti,Shannon, Harlan E.,Bleakman, David,Alt, Andrew,Arnold, Brian M.,Bell, Michael G.,Bleisch, Thomas J.,Buckmaster, Jennifer L.,Castano, Ana M.,Del Prado, Miriam,Escribano, Ana,Filla, Sandra A.,Ho, Ken H.,Hudziak, Kevin J.,Jones, Carrie K.,Martinez-Perez, Jose A.,Mateo, Ana,Mathes, Brian M.,Mattiuz, Edward L.,Ogden, Ann Marie L.,Simmons, Rosa Maria A.,Stack, Douglas R.,Stratford, Robert E.,Winter, Mark A.,Wu, Zhipei,Ornsteint, Paul L.
, p. 4200 - 4203 (2007/10/03)
Amino acids 5 and 7, two potent and selective competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. Their ester prodrugs 6 and 8 were orally active in three models of pain: reversal of formalin-i
