503305-89-3Relevant academic research and scientific papers
A Concise Total Synthesis of (+)-FR900482 and (+)-FR66979
Judd, Ted C.,Williams, Robert M.
, p. 2825 - 2830 (2007/10/03)
The concise, enantioselective total synthesis of the potent antitumor antibiotics (+)-FR900482 and (+)-FR66979 are described. Sharpless asymmetric epoxidation technology has been deployed to construct the optically active aziridine-containing fragment tha
Concise enantioselective synthesis of (+)-FR66979 and (+)-FR900482: Dimethyldioxirane-mediated construction of the hydroxylamine hemiketal
Judd, Ted C.,Williams, Robert M.
, p. 4683 - 4685 (2007/10/03)
The remarkable one-step deprotection/oxidative cyclization of an eight-membered-ring aminoketone 1 in the presence of dimethyldioxirane gives rise to the unique hydroxylamine hemiketal ring system of FR66979 (2) and FR900482 (3), clinically important anti
