50339-38-3Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors
Zhou, Du-Chao,Lu, Yu-Ting,Mai, Yan-Wen,Zhang, Chen,Xia, Jie,Yao, Pei-Fen,Wang, Hong-Gen,Huang, Shi-Liang,Huang, Zhi-Shu
, (2019/08/06)
For the development of novel anticancer agents, we designed and synthesized a total of 37 perimidine o-quinone derivatives containing the o-quinone group at the A or B ring and different substituents (alkyl groups, aryl groups or heterocycles) at the C ri
2-Arylperimidine derivatives. Part 1. Synthesis, NMR spectroscopy, X-ray crystal and molecular structures
Llamas-Saiz, Antonio L.,Foces-Foces, Concepcion,Sanz, Dionisia,Claramunt, Rosa M.,Dotor, Julio,et al.
, p. 1389 - 1398 (2007/10/02)
The synthesis and NMR spectroscopy of seven 2-phenyl, 2-(2-hydroxyphenyl)- and 2-(2-methoxyphenyl)-perimides 1-7 are described.The X-ray structural characterization of four perimidine derivatives: 2-(2-hydroxyphenyl)perimidine (2), 2-(9-anthryl)perimidine
HETEROCYCLIC ANALOGS OF PLEIADIENE. 48. PYROSULFITE AS A MILD DEHYDROGENATING AGENT IN THE 2,3-DIHYDROPERIMIDINE SERIES. SYNTHESIS OF 2-POLYHYDROXYALKYLPERIMIDINES
Starshikov, N.M.,Pozharskii, A.F.
, p. 81 - 85 (2007/10/02)
2,3-Dihydroperimidines are dehydrogenated smoothly by sodium pyrosulfite in refluxing aqueous alcohol, as a result of which the corresponding perimidines are formed in high yields.The reaction of 1,8-naphthalenediamine with the aldehydic forms of sugars gives 2-polyhydroxyalkyl-2,3-dihydroperimidines, which are also aromatized by sodium pyrosulfite to give the corresponding 2-polyhydroxyalkylperimidines in high yields.
