503447-25-4

Upstream product

• 71435-31-9 N-Benzyl-N-(2-phenyl-2-cyanovinyl)-glycin-ethylester 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 5841-70-3 phenyl(formyl)acetonitrile 
• 71435-34-2 ethyl 3-amino-1-benzyl-4-phenyl-1H-pyrrole-2-carboxylate 

Downstream Products

• 503447-26-5 6-benzyl-3,8-diphenyl-4H-pyrrolo[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(6H)-one 

Relevant academic research and scientific papers

New tricyclic systems of biological interest. Annelated 1,2,3-triazolo[1,5-a]pyrimidines through domino reaction of 3-azidopyrroles and methylene active nitriles

Anionic hetero-domino reaction of 3-azidopyrroles and acetonitriles constitutes the synthetic entry to annelated 1,2,3-triazolo[1,5-a]pyrimidines. Upon slight variations of the experimental conditions the method is of general application either with 2 or 4 substituted pyrroles. Thus derivatives of the new ring system pyrrolo[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine, isomers of the previously synthesized pyrrolo[3,4-e][1,2,3]triazolo[1,5-a]pyrimidine, were prepared in high yields. The condensed pyrrolo-triazolo-pyrimidines, although only moderately active, can be used as model for the design of DNA-interactive compounds.