71435-34-2Relevant academic research and scientific papers
New tricyclic systems of biological interest. Annelated 1,2,3-triazolo[1,5-a]pyrimidines through domino reaction of 3-azidopyrroles and methylene active nitriles
Lauria, Antonino,Diana, Patrizia,Barraja, Paola,Montalbano, Alessandra,Cirrincione, Girolamo,Dattolo, Gaetano,Almerico, Anna Maria
, p. 9723 - 9727 (2007/10/03)
Anionic hetero-domino reaction of 3-azidopyrroles and acetonitriles constitutes the synthetic entry to annelated 1,2,3-triazolo[1,5-a]pyrimidines. Upon slight variations of the experimental conditions the method is of general application either with 2 or 4 substituted pyrroles. Thus derivatives of the new ring system pyrrolo[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine, isomers of the previously synthesized pyrrolo[3,4-e][1,2,3]triazolo[1,5-a]pyrimidine, were prepared in high yields. The condensed pyrrolo-triazolo-pyrimidines, although only moderately active, can be used as model for the design of DNA-interactive compounds.
