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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-aminophenyl)-3-pyrrolidinol is used as a key intermediate for the development of various drugs, leveraging its unique chemical properties to enhance the efficacy and pharmacological profile of the final drug products.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-aminophenyl)-3-pyrrolidinol is utilized as a building block in the synthesis of agrochemicals, contributing to the development of innovative and effective products for crop protection and enhancement.
Used in Organic Chemistry Research:
1-(4-aminophenyl)-3-pyrrolidinol serves as a valuable reagent in organic chemistry research, facilitating the exploration of new synthetic pathways and the discovery of novel chemical compounds with potential applications across various industries.
Used in Production of Chemical Products:
As a key intermediate, 1-(4-aminophenyl)-3-pyrrolidinol is employed in the production of a wide range of chemical products, including complex organic molecules, showcasing its versatility and importance in the chemical industry.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 361346-55-6 1-(4-nitrophenyl)pyrrolidin-3-ol 

Relevant academic research and scientific papers

PURINE DERIVATIVES

Purine derivatives of Formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.

PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS

Pyrrolopyrimidine derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.

THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY

To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: -CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].

Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases such as cancer. The pyrido[2,3-d]-pyrimidin-7-one template has been identified previously as a privileged structure for the inhibition of ATP-dependent kinases, and good potency against Cdks has been reported for representative examples. Obtaining selectivity for individual Cdk enzymes, particularly Cdk4, has been challenging. Here, we report that the introduction of a methyl substituent at the C-5 position of the pyrido[2,3-d]pvrimidin-7-one template is sufficient to confer excellent selectivity for Cdk4 vs other Cdks and representative tyrosine kinases. Further optimization led to the identification of highly potent and selective inhibitors of Cdk4 that exhibit potent antiproliferative activity against human tumor cells in vitro. The most selective Cdk4 inhibitors were evaluated for antitumor activity against MDA-MB-435 human breast carcinoma xenografts in mice.