503551-88-0Relevant academic research and scientific papers
2,6-DIOXASPIRO [4,5] DECANE DERIVATIVES AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATIONS THEREOF
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Paragraph 0148-0149, (2020/08/25)
The present invention relates to a series of 2,6-dioxaspiro [4,5] decane derivatives and applications thereof in preparation of opiate receptor p agonist related drugs; and in particular relates to the derivative compounds shown in formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.
Multicomponent reactions: Synthesis of spirocyclic tetrahydropyran derivatives by prins cyclization
Ghosh, Arun K.,Shin, Dongwoo,Schiltz, Gary
, p. 659 - 666 (2007/10/03)
Substituted spirocyclic tetrahydropyranyl mesylates and tosylates have been synthesized in good yields using a Prins-type cyclization of various cyclic ketones, a homoallylic alcohol and either methanesulfonic or p-toluenesulfonic acid under non-aqueous conditions. The mesylates thus produced could then be transformed into the corresponding Boc-protected amines using an efficient two step procedure.
