503590-46-3Relevant academic research and scientific papers
A Robust One-Step Approach to Ynamides
Tu, Yongliang,Zeng, Xianzhu,Wang, Hui,Zhao, Junfeng
supporting information, p. 280 - 283 (2018/01/17)
A robust one-step synthetic strategy for ynamide with cheap and easily available stock chemicals vinyl dichlorides and electron deficient amides as the starting material is described. In the absence of transition-metal catalyst, the reaction proceeds under mild reaction conditions in open air and thus rendering a convenient operation. This strategy is not only suitable for both terminal and internal ynamide synthesis but also amenable for large-scale preparation. Broad substrate scopes with respect to vinyl dichloride as well as electron-deficient amide were observed.
Highly substituted 2-amido-furans from rh(ll)-catalyzed cyclopropenations of ynamides
Li, Hongyan,Hsung, Richard P.
supporting information; experimental part, p. 4462 - 4465 (2009/12/24)
Rh(II)-catalyzed cyclopropenations of ynamides are described. Although an actual amido-cyclopropene intermediate may not be involved, these reactions provide a facile entry to highly substituted 2-amido-furans, thereby formerly constituting a [3 + 2] cycloaddition. An application of these de novo 2-amido-furans In N-tethered intramolecular [4 + 2] cycloadditions is also illustrated, leading to dihydroindoles and tetrahydroqulnolines
New stannyl enamides
Naud, Se?bastien,Cintrat, Jean-Christophe
, p. 1391 - 1397 (2007/10/03)
New stannyl enamines derived from N-ethynyl oxazolidin-2-ones have been obtained. We describe for the first time the preparation of N-ethynyl oxazolidin-2-ones using trimethylsilylethynyl iodonium triflate. The first results of transmetallation and quenching experiments with prochiral carbonyl derivatives to give β-amino alcohols are also described.
A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides
Frederick, Michael O.,Mulder, Jason A.,Tracey, Michael R.,Hsung, Richard P.,Huang, Jian,Kurtz, Kimberly C. M.,Shen, Lichun,Douglas, Christopher J.
, p. 2368 - 2369 (2007/10/03)
A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides. Copyright
