503597-56-6

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 3282-30-2 pivaloyl chloride 
• 106454-69-7 N-tert-butoxycarbonyl-D-Phenylalaninol 

Downstream Products

• 824937-67-9 N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(S)-α-methyl-4-aminobenzyl]thiourea 
• 824937-62-4 N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea 
• 824937-60-2 (2R)-3-phenyl-1-pivaloyloxy-2-propyl isothiocyanate 
• 503597-57-7 (2R)-3-phenyl-1-pivaloyloxy-2-propyl amine 

Relevant academic research and scientific papers

α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists

A series of α-methylated analogues of the potent sRTX thiourea antagonists were investigated as rTRPV1 ligands in order to examine the effect of α-methylation on receptor activity. The SAR analysis indicated that activity was stereospecific with the (R)-configuration of the newly formed chiral center providing high binding affinity and potent antagonism while the configuration of the C-region was not significant.