50361-97-2

Upstream product

• 931-20-4 1-methylpiperidin-2-one 
• 98-88-4 benzoyl chloride 
• 1934-92-5 N-methyl-N-phenyl-benzamide 

Downstream Products

• 116461-08-6 N-allyl-3-oxo-3-phenyl propionic amide 

Relevant academic research and scientific papers

Nickel-Catalyzed Claisen Condensation Reaction between Two Different Amides

A nickel-catalyzed Claisen condensation reaction between two amides, where one possesses an α-proton, for the synthesis of β-ketoamides was developed. Ni(glyme)Cl2 and terpyridine serve as the active catalysts in the presence of Mn and LiCl. N,N-Methylphenyl and N,N-diphenyl benzamide derivatives react with cyclic and noncyclic amides to give their corresponding β-ketoamides in moderate to good yields. In addition, a DFT calculation suggests that reductive elimination is the rate-determining step.

PHOTOCYCLISATION OF KETO-LACTAMS. A NEW SYNTHESIS OF FUNCTIONALIZED 1-AZA-BICYCLO(X.Y.0.)ALKANES

A series of 1-azabicyclo(x.y.0)alkanes has been synthesized using an intramolecular photoreduction.The methodology consists of a regioselective abstraction of a hydrogen α to the nitrogen of an amide by the triplet T1(n, ?*) of a carbonyl derivative.