50375-21-8Relevant academic research and scientific papers
A new strategy for synthesis of polymeric supports with triazene linkers
Lazny, Ryszard,Nodzewska, Aneta,Klosowski, Piotr
, p. 121 - 130 (2007/10/03)
A new strategy based on the use of diethylamine triazenes for stabilization and generation of polymer supported diazonium ions was described. New economical syntheses of four new polymeric supports with 3- and 6-carbon atom spacers and triazene linkers derived from meta- and para-aminophenol were described and compared to the traditional methods. The possible application of the polymer bound triazene masked diazonium salts as supports for immobilization of secondary amines (nortropine and 4-piperidinole and their esterification and oxidation), and as amine scavengers was shown. The new supports with meta-C3-T2 and para-C3-T2 linkers showed higher loadings and typically gave products with good yields and purities.
Multistep solution-phase parallel synthesis of spiperone analogues
Hansen, Henrik C.,Olsson, Roger,Croston, Glenn,Andersson, Carl-Magnus
, p. 2435 - 2439 (2007/10/03)
A flexible, multistep parallel synthesis of spiperone analogues is described. A library of 4-substituted piperidines, assembled utilizing reductive amination and acylation protocols, was alkylated either homogeneously or heterogeneously, exploiting a product release only concept, to afford an oxa-series of spiperone analogues. Screening of the products at 5-HT2 and D2 receptors revealed 5-HT(2A) antagonists with improved selectivity compared to spiperone and AMI-193. (C) 2000 Published by Elsevier Science Ltd.
