5038-12-0Relevant academic research and scientific papers
Facile hydrolysis and formation of amide bonds by N-hydroxyethylation of α-amino acids
Suggs, J. William,Pires, Richard M.
, p. 2227 - 2230 (1997)
The C-terminal amides of α-amino acids are readily hydrolyzed at 25°and pH 7 when the N-terminus is N-hydroxyethylated, with one or two hydroxyethyl The reaction proceeds via cyclization to a morpholinolactone (2) which is rapidly hydrolyzed by water. In the presence of equimolar amounts of amines or amino acid derivatives, 2 reacts in H2O without condensing agents to form a new peptide bond.
