50390-68-6

Basic information

• Product Name: 2-METHYL-2-PHENYL-CYCLOPENTANONE
• Synonyms: 2-METHYL-2-PHENYL-CYCLOPENTANONE;2-Phenyl-2-methylcyclopentanone
• CAS NO: 50390-68-6
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.23896
• Mol File: 50390-68-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 277 °C at 760 mmHg
• Flash Point: 114.1 °C
• Appearance: /
• Density: 1.038 g/cm³
• Vapor Pressure: 0.00465mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 2-METHYL-2-PHENYL-CYCLOPENTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2-PHENYL-CYCLOPENTANONE(50390-68-6)
• EPA Substance Registry System: 2-METHYL-2-PHENYL-CYCLOPENTANONE(50390-68-6)

Safety Data

• Hazardous Substances Data: 50390-68-6(Hazardous Substances Data)

Usage

General Description

2-Methyl-2-phenyl-cyclopentanone is a chemical compound with the molecular formula C12H14O. It is a cyclic ketone with a unique structure that includes a five-membered ring with a methyl and phenyl group attached. 2-METHYL-2-PHENYL-CYCLOPENTANONE is commonly used as a building block in organic synthesis and can be used to create a variety of different chemical products. It is also used in the production of fragrances and flavors due to its pleasant aroma. Additionally, it has been studied for its potential pharmaceutical applications, particularly in the development of new drugs. Overall, 2-methyl-2-phenyl-cyclopentanone has a wide range of industrial and commercial applications due to its unique chemical properties.

InChI:InChI=1/C12H14O/c1-12(9-5-8-11(12)13)10-6-3-2-4-7-10/h2-4,6-7H,5,8-9H2,1H3

Upstream product

• 108-86-1 bromobenzene 
• 19980-34-8 trimethyl-(2-methyl-cyclopent-1-enyloxy)-silane 
• 1191-95-3 cyclobutanone 
• 22293-10-3 (1-diazoethyl)benzene 
• 120-92-3 cyclopentanone 
• 100-58-3 phenylmagnesium bromide 
• 825-54-7 cyclopent-1-en-1-ylbenzene 
• 53847-19-1 5-phenyl-5-hexanal 
• 127047-12-5 5-phenyl-hex-5-en-1-ol 
• 98-80-6 phenylboronic acid 
• 928-90-5 5-hexyl-1-ol 
• 75750-06-0 2-phenyl-2-methylcyclobutanone 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 719272-47-6 1-methyl-2-phenyl-cyclopentane-1,2-diol 

Downstream Products

• 1263869-70-0 7-methyl-7-phenyl-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione 
• 1263869-68-6 2,4-dichloro-7-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine 
• 1263869-71-1 2-chloro-N-ethyl-7-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263869-69-7 7-methyl-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazine-2,4(3H,5H)-dione 
• 86029-88-1 cis-methyl-2-methyl-2-phenylcyclobutane carboxylate 
• 88726-50-5 2-Methoxy-5-methyl-5-phenyl-cyclopent-2-enone 
• 2972-25-0 5-phenylhexanoic acid 

Relevant articles and documents

The Asymmetric Cyclisation of Substituted Pent-4-enals by a Chiral Rhodium Phosphine Catalyst

Treatment of the racemic disubstituted pent-4-enals (1) and (2) at ca. 150 deg C with the chiral complex Cl results in a cyclisation reaction and catalytic asymmetric synthesis of the 2,2- and 3,3-disubstituted cyclopentanones (3) and (4), respectively.

Enantioselective Intramolecular Hydroacylation of Unactivated Alkenes: An NHC-Catalyzed Robust and Versatile Formation of Cyclic Chiral Ketones

A highly enantioselective intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation reaction gives access to a range of cyclic ketones from unactivated olefin-substituted aldehydes (up to 99% ee). Remarkably, aliphatic aldehydes were also transformed efficiently in an NHC-catalyzed hydroacylation reaction for the first time. 100% Organic: A highly enantioselective N-heterocyclic carbene (NHC)-catalyzed intramolecular hydroacylation of aromatic and, more interestingly, aliphatic aldehydes with unactivated olefins offers access to a range of cyclic α-chiral ketones bearing quaternary centers. The reaction was found to be highly robust and proceeds with excellent yield in the presence of a diverse range of functional groups.

Highly efficient and enantioselective α-arylation of cycloalkanones by scandium-catalyzed diazoalkane-carbonyl homologation

Functionalized α-tertiary and -quaternary 2-arylcycloalkanones are rapidly accessed by scandium(III) triflate-catalyzed diazo-alkane-carbonyl homologations. Recent developments have allowed for carbon insertion reactions to be performed with catalyst loadings as low as 0.5 mol% on scales up to 5 mmol. Pairing readily available bis- and tris(oxazoline) based ligands with scandium triflate allows access to arylated medium ring carbocycles with enantioselectivities up to 98:2 er and >98% yield. The formal C-C insertion of aryldiazo-methanes into unsubstituted cycloalkanones provides a single-step solution to the ongoing challenge of α-arylation. Georg Thieme Verlag Stuttgart · New York.