2972-25-0

Upstream product

• 50390-68-6 (±)-2-methyl-2-phenylcyclopentanone 
• 4219-24-3 hex-3-enoic acid 
• 71-43-2 benzene 
• 13984-50-4 methyl levulinate 
• 4224-62-8 6-chlorohexanoic acid 
• 13317-80-1 methyl 5-phenylhexanoate 
• 110-44-1 sorbic Acid 
• 7446-70-0 aluminium trichloride 
• 3128-06-1 5-ketohexanoic acid 
• 107771-41-5 ethyl 5-phenylhexanoate 
• 2722-36-3 3-phenyl-1-butanol 
• 91404-32-9 (3-iodo-1-methyl-propyl)-benzene 
• 4593-90-2 3-phenylbutyric acid 

Downstream Products

• 51193-71-6 6-phenyl-2-heptanone 
• 105907-95-7 5-phenyl-hexanoyl chloride 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed Enantioselective Arylation of Unbiased Methylene C(sp3)?H Bonds Enabled by a 2-Pyridinylisopropyl Auxiliary and Chiral Phosphoric Acids

Enantioselective functionalizations of unbiased methylene C(sp3)?H bonds of linear systems by metal insertion are intrinsically challenging and remain a largely unsolved problem. Herein, we report a palladium(II)-catalyzed enantioselective arylation of unbiased methylene β-C(sp3)?H bonds enabled by the combination of a strongly coordinating bidentate PIP auxiliary with a monodentate chiral phosphoric acid (CPA). The synergistic effect between the PIP auxiliary and the non-C2-symmetric CPA is crucial for effective stereocontrol. A broad range of aliphatic carboxylic acids and aryl bromides can be used, providing β-arylated aliphatic carboxylic acid derivatives in high yields (up to 96 %) with good enantioselectivities (up to 95:5 e.r.). Notably, this reaction also represents the first palladium(II)-catalyzed enantioselective C?H activation with less reactive and cost-effective aryl bromides as the arylating reagents. Mechanistic studies suggest that a single CPA is involved in the stereodetermining C?H palladation step.

Substituted guanidine derivatives and process for producing the same

A compound represented by the general formula (1): wherein each of R1, R2, R3, R4and R5is a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a saturated heterocyclic group, an aromatic group, an acyl group or the like; each of Y1, Y2, Y3and Y4is a single bond, —CH2—, —O—, —CO— or the like, provided that at least two of Y1through Y4are independently a group other than a single bond; and Z may be absent, or one or more Zs may be present and are independently an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a saturated heterocyclic group, a halogen atom, a carboxyl group, an alkoxycarbonyl group, an aromatic group, an acyl group or the like, is useful as a therapeutic or prophylactic agent for diseases caused by the acceleration of the sodium/proton exchange transport system.

Some Aspects of the Chemistry of Benzosuberone: Novel synthesis of the 5,9-methano-5H-benzocycloheptene and 6,9-ethano-5H-benzocycloheptene ring systems.

5-Cyano-7-(dimethylamino)-5-phenylheptanoic acid (3; R1=H, R2=CN) and its derivatives could not be cyclised to benzosuberones but yielded with PPA, 3-(dimethylaminoethyl)-3-phenyl-2,7(1H)-dioxoazepane (6) and 6-(dimethylaminoethyl)-6

LIGHT-INDUCED FREE-RADICAL REACTIONS OF 2-METHOXY-6-METHYLTETRAHYDROPYRAN: IRREVERSIBLE RING OPENING AND MULTISITE HYDROGEN ABSTRACTION

Acetophenone-initiated photodegradation of cis-2-methoxy-4-methyltetrahydropyran (7) in benzene solvent produced six products.The structures of the products, and studies using optically active 7, showed that hydrogen abstraction occurs at both C-2 and C-6 of the tetrahydropyran ring.The products derived from the C-2 radical indicated two pathways for this radical: ring opening and loss of methyl, which is consistent with previous work on other similar systems.Results with optically active 7 showed that the ring-opening pathway is irreversible.Generation of an open-chain radical independently also showed that cyclization to a six membered ring does not occur.The products from the photodegradation were trans-2-methoxy-6-methyltetrahydropyran (8), methyl hexanoate (10), 6-methyltetrahydropyran-2-one (9), methyl 5-phenylhexanoate (11), 1,7-dimethyl-7-phenyl-6,8-dioxobicyclooctane (13), and 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran (12).The yield of lactone 9 was found to be sensitive to the amount of residual oxygen present during the photolysis.