2972-25-0

Basic information

• Product Name: 5-PHENYL HEXANOIC ACID
• Synonyms: 5-PHENYL HEXANOIC ACID
• CAS NO: 2972-25-0
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25424
• Mol File: 2972-25-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-PHENYL HEXANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL HEXANOIC ACID(2972-25-0)
• EPA Substance Registry System: 5-PHENYL HEXANOIC ACID(2972-25-0)

Safety Data

• Hazardous Substances Data: 2972-25-0(Hazardous Substances Data)

Upstream product

• 4224-62-8 6-chlorohexanoic acid 
• 71-43-2 benzene 
• 13317-80-1 methyl 5-phenylhexanoate 
• 4593-90-2 3-phenylbutyric acid 
• 91404-32-9 (3-iodo-1-methyl-propyl)-benzene 
• 2722-36-3 3-phenyl-1-butanol 
• 107771-41-5 ethyl 5-phenylhexanoate 
• 3128-06-1 5-ketohexanoic acid 
• 110-44-1 sorbic Acid 
• 7446-70-0 aluminium trichloride 
• 13984-50-4 methyl levulinate 
• 4219-24-3 hex-3-enoic acid 
• 50390-68-6 (±)-2-methyl-2-phenylcyclopentanone 

Downstream Products

• 105907-95-7 5-phenyl-hexanoyl chloride 
• 51193-71-6 6-phenyl-2-heptanone 

Relevant articles and documents

Palladium(II)-Catalyzed Enantioselective Arylation of Unbiased Methylene C(sp3)?H Bonds Enabled by a 2-Pyridinylisopropyl Auxiliary and Chiral Phosphoric Acids

Enantioselective functionalizations of unbiased methylene C(sp3)?H bonds of linear systems by metal insertion are intrinsically challenging and remain a largely unsolved problem. Herein, we report a palladium(II)-catalyzed enantioselective arylation of unbiased methylene β-C(sp3)?H bonds enabled by the combination of a strongly coordinating bidentate PIP auxiliary with a monodentate chiral phosphoric acid (CPA). The synergistic effect between the PIP auxiliary and the non-C2-symmetric CPA is crucial for effective stereocontrol. A broad range of aliphatic carboxylic acids and aryl bromides can be used, providing β-arylated aliphatic carboxylic acid derivatives in high yields (up to 96 %) with good enantioselectivities (up to 95:5 e.r.). Notably, this reaction also represents the first palladium(II)-catalyzed enantioselective C?H activation with less reactive and cost-effective aryl bromides as the arylating reagents. Mechanistic studies suggest that a single CPA is involved in the stereodetermining C?H palladation step.

Some Aspects of the Chemistry of Benzosuberone: Novel synthesis of the 5,9-methano-5H-benzocycloheptene and 6,9-ethano-5H-benzocycloheptene ring systems.

5-Cyano-7-(dimethylamino)-5-phenylheptanoic acid (3; R1=H, R2=CN) and its derivatives could not be cyclised to benzosuberones but yielded with PPA, 3-(dimethylaminoethyl)-3-phenyl-2,7(1H)-dioxoazepane (6) and 6-(dimethylaminoethyl)-6

LIGHT-INDUCED FREE-RADICAL REACTIONS OF 2-METHOXY-6-METHYLTETRAHYDROPYRAN: IRREVERSIBLE RING OPENING AND MULTISITE HYDROGEN ABSTRACTION

Acetophenone-initiated photodegradation of cis-2-methoxy-4-methyltetrahydropyran (7) in benzene solvent produced six products.The structures of the products, and studies using optically active 7, showed that hydrogen abstraction occurs at both C-2 and C-6 of the tetrahydropyran ring.The products derived from the C-2 radical indicated two pathways for this radical: ring opening and loss of methyl, which is consistent with previous work on other similar systems.Results with optically active 7 showed that the ring-opening pathway is irreversible.Generation of an open-chain radical independently also showed that cyclization to a six membered ring does not occur.The products from the photodegradation were trans-2-methoxy-6-methyltetrahydropyran (8), methyl hexanoate (10), 6-methyltetrahydropyran-2-one (9), methyl 5-phenylhexanoate (11), 1,7-dimethyl-7-phenyl-6,8-dioxobicyclooctane (13), and 2-methoxy-2-(1-phenyl-1-hydroxyethyl)-6-methyltetrahydropyran (12).The yield of lactone 9 was found to be sensitive to the amount of residual oxygen present during the photolysis.