50398-78-2

Usage

Uses

Used in Pharmaceutical Industry:
(5-chloro-1,3-thiazol-2-yl)methanol is used as a reagent for the preparation of dihydronaphthalenylpyridone derivatives. These derivatives serve as melanin-concentrating hormone receptor 1 (MCHR1) antagonists, which have potential applications in the treatment of various conditions such as obesity, depression, and cognitive disorders. (5-chloro-1,3-thiazol-2-yl)methanol's reactivity and structural features make it a valuable building block in the development of these therapeutic agents.

Upstream product

• 59129-52-1 5-chlorothiazole-2-carboxaldehyde 

Relevant academic research and scientific papers

CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula (I), independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and 15 deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.