504-70-1Relevant academic research and scientific papers
NOVEL AROMATIC COMPOUND AND POLYARYLENE COPOLYMER HAVING NITROGEN-CONTAINING HETEROCYCLE INCLUDING SULFONIC ACID GROUP IN SIDE CHAIN
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, (2010/06/22)
Provided is a solid polymer electrolyte having increased heat resistance and high proton conductivity and a proton conductive membrane composed of the electrolyte. Also provided is a copolymer having a sulfonic acid group. The copolymer includes a repeating unit represented by Formula (1): (in the formula, Y denotes at least one kind of structure selected from the group consisting of —CO—, —SO2—, —SO—, —CONH—, —COO—, —(CF2)l— (l is an integer of 1 to 10), and —C(CF3)2—; W denotes at least one kind of structure selected from the group consisting of a direct bond, —CO—, —SO2—, —SO—, —CONH—, —COO—, —(CF2)l— (l is an integer of 1 to 10), —C(CF3)2—, —O—, and —S—; Z denotes a direct bond or at least one kind of structure selected from the group consisting of —(CH2)l—(l is an integer of 1 to 10), —C(CH3)2—, —O—, —S—, —CO—, and —SO2—; R30 denotes a nitrogen-containing aromatic ring having a substituent represented by —SO3H, —O(CH2)hSO3H, or —O(CF2)hSO3H (h is an integer of 1 to 12); p is an integer of 0 to 10; q is an integer of 0 to 10; r is an integer of 1 to 5; and k is an integer of 0 to 4).
Hepatitis C Virus Inhibitors
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, (2010/11/03)
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects
Wilkinson, Douglas E.,Thomas IV, Bert E.,Limburg, David C.,Holmes, Agnes,Sauer, Hansjorg,Ross, Douglas T.,Soni, Raj,Chen, Yi,Guo, Hong,Howorth, Pamela,Valentine, Heather,Spicer, Dawn,Fuller, Mike,Steiner, Joseph P.,Hamilton, Gregory S.,Wu, Yong-Qian
, p. 4815 - 4825 (2007/10/03)
Nonimmunosuppressant ligands, exemplified by GPI 1046 (1), for the peptidyl-prolyl isomerase FKBP12 have been found to unexpectedly possess powerful neuroprotective and neuroregenerative effects in vitro and in vivo. We have extensively explored the thera
Iminium-Ion Formation and Deuterium Exchange by Acetone in the Presence of Pyrrolidine, Pyrazolidine, Isoxazolidine, and Their Acyclic Analogues
Hine, Jack,Evangelista, Ramon A.
, p. 1649 - 1655 (2007/10/02)
Equilibrium constants for iminium-ion formation in the reaction of acetone in aqueous solution at 35 deg C with pyrazolidinium, isoxazolidinium, O,N-dimethylhydroxylammonium, and N,N'-dimethylhydrazinium ions were found to be 9.33, 8.96, 0.117, and 0.057 M-1, respectively.The kinetics of hydrolysis of the iminium ions were studied in every case except that of the N-isopropylidene-O,N-dimethylhydroxylammonium ion, whose hydrolysis is too fast to follow by the techniques used with the other iminium ions.The rate of hydrolysis of the N-isopropylidenepyrazolium ion is independent of the pH from about pH 3 to 6; it is hydrogen ion catalyzed at lower pHs and hydroxide ion catalyzed at higher pHs.The rate of hydrolysis of N-isopropylideneisoxazolidinium ions is pH independent from pH 0.5 to about 2, increases until about pH 4, remains pH independent until pH 6.5, and has become too fast to measure above pH 8.Both reactions are general base catalyzed in all the buffers studied.A mechanism is described to fit the kinetics of each of these reactions.The dedeuteration of acetone-d6 was studied in pyridine buffers in the presence of each of the four hydrazine and hydroxylamine derivatives and also in the presence of the dimethylammonium and pyrrolidinium ion (which was also studied in 3-dimethylaminopropionitrile buffers).All six of these secondary ammonium ions catalyze the dedeuteration by transforming the acetone-d6 to an iminium ion that is dedeuterated by pyridine more rapidly than the ketone is.The iminium-ion formation is a relatively rapid eqiuilibrium in all cases except that of pyrrolidinium ions, where the intermediate iminum ion loses deuterium and hydrolyzes at comparable rates, and possibly the case of dimethylammonium ions, where the amount of catalysis via iminium-ion formation is too small to reveal mechanistic details.The effect of structure on the efficiency of catalysis of dedeuteration via iminium-ion formation is discussed.
Novel pyrazolidines useful as herbicides
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, (2008/06/13)
This invention relates to pyrazolidine compounds, to a method for preparing the same by the reduction of either a pyrazolium or a pyrazolinium salt, and to a method for controlling undesirable plant species therewith.
Pyrazolidine fungicides
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, (2008/06/13)
There is provided a method for protecting plants from attack by fungi by applying to said plants a fungicidally effective amount of a pyrazolidine and acid salt derivatives thereof.
