50402-56-7

Basic information

• Product Name: 1,5-EDANS
• Synonyms: N-(AMINOETHYL)-5-NAPHTHYLAMINE-1-SULFONIC ACID;N-(2-AMINOETHYL)-5-NAPHTHYLAMINE-1-SULPHONIC ACID;EDANS;EDANS ACID;1,5-EDANS;5-(2-AMINOETHYLAMINO)-1-NAPHTHALENE SULFONIC ACID;5-((2-AMINOETHYL)AMINO)NAPHTHALENE-1-SULFONIC ACID;5-(2-aminoethylamino)-1-naphthalene-*sulfonic aci
• CAS NO: 50402-56-7
• Molecular Formula: C₁₂H₁₄N₂O₃S
• Molecular Weight: 266.32
• EINECS: 256-575-5
• Product Categories: Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;MTS & Sulfhydryl Active Reagents;Amines;Aromatics;Sulfur & Selenium Compounds;Fluorescent Dyes
• Mol File: 50402-56-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: >350°C
• Appearance: /
• Density: 1.432 g/cm³
• Refractive Index: 1.691
• Storage Temp.: Refrigerator
• Solubility: Aqueous Base (Slightly), DMSO (Slightly, Heated)
• PKA: -0.37±0.40(Predicted)
• CAS DataBase Reference: 1,5-EDANS(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-EDANS(50402-56-7)
• EPA Substance Registry System: 1,5-EDANS(50402-56-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-27-36/37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 50402-56-7(Hazardous Substances Data)

Usage

Chemical Properties

Gray-yellow Crystalline Powder

Uses

A fluorescent reagent with a terminal amine for derivatization. 1,5-EDANS has similar spectral properties to the naphthalenesulfonic acids. Fluorescence: max. Abs. 335nm; max. Em. 493nm; e x 10-3: 5.9

InChI:InChI=1/C12H14N2O3S/c13-7-8-14-11-5-1-4-10-9(11)3-2-6-12(10)18(15,16)17/h1-6,14H,7-8,13H2,(H,15,16,17)

Upstream product

• 1606181-57-0 2-(6-methyl-1,2,4,5-tetrazin-3-yl)acetic acid 
• 1558-23-2 3,6-dimethyl-1,2,4,5-tetrazine 
• 5419-77-2 6-Hydroxy-2-naphthalene sulfonic acid sodium salt 
• 107-15-3 ethylenediamine 

Downstream Products

• 816430-11-2 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid 
• 1375413-65-2 5-((2-(4-azidobenzamido)ethyl)amino)naphthalene-1-sulfonic acid 
• 143774-97-4 Boc-Glu(EDANS)-OBzl 

Relevant articles and documents

Redox-based selective fluorometric detection of homocysteine

Plasma homocysteine (Hcy) is an important risk factor for various diseases. A novel redox-sensitive fluorescent probe is developed for the selective detection of Hcy. A linear calibration curve has been obtained in buffer and plasma for the quantitative determination of Hcy in such media. This journal is

Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics

The inverse electron demand Diels–Alder pyridazine elimination reaction between tetrazines and allylic substituted trans-cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of alkylamine substrates has so far proven difficult. Here, we report a fluorogenic tool consisting of a TCO-linked EDANS fluorophore and a DABCYL quencher for accurate determination of both the click and release rate constants for any tetrazine at physiologically relevant concentrations.

Multiconstituent liquid lgG and IgM calibrators

A serum in which are dissolved at least two heterologous antibodies, which are independently IgG or IgM and which specifically bind to different antigens, serves as a calibrator for multi-analyte immunoassays.