50408-18-9Relevant academic research and scientific papers
Efficient synthesis of [2′-18O]uridine and its incorporation into oligonucleotides: A new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis
Dai, Qing,Frederiksen, John K.,Anderson, Vernon E.,Harris, Michael E.,Piccirilli, Joseph A.
, p. 309 - 311 (2008/09/17)
(Chemical Equation Presented) Lack of sufficient quantities of isotopically labeled materials has precluded the use of heavy atom isotope effects to investigate mechanisms of nucleotidyl transfer reactions in nucleic acids. Here we achieve regioselective
A universal adapter for chemical synthesis of DNA or RNA on any single type of solid support
Schwartz,Breaker,Asteriadis,Gough
, p. 27 - 30 (2007/10/02)
Use of a novel nucleotide adapter, 2'(3')-O-dimethoxytrityl-3'(2')-O-benzoyluridine-5'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) eliminates the need to have eight separate solid supports for synthesis of all possible oligoribo- and oligodeoxyribonucleotides.
