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4(3H)-Quinazolinone, 2-amino-5-chloro-, also known as 2-amino-5-chloroquinazolinone, is a chemical compound with the molecular formula C8H6ClN3O. It is a quinazolinone derivative featuring a chlorine atom at the 5th position and an amino group at the 2nd position of the quinazolinone ring. 4(3H)-Quinazolinone, 2-amino-5-chlorohas been studied for its potential pharmacological activities, such as antitumor and antifungal properties, and is considered an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a promising candidate for further research and development in medicinal chemistry and pharmaceutical sciences.

50440-85-2

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50440-85-2 Usage

Uses

Used in Pharmaceutical Industry:
4(3H)-Quinazolinone, 2-amino-5-chlorois used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure and properties make it a valuable building block in the development of new therapeutic agents.
Used in Medicinal Chemistry Research:
4(3H)-Quinazolinone, 2-amino-5-chlorois used as a research tool in medicinal chemistry to explore its potential pharmacological activities, such as antitumor and antifungal properties. Its structure and properties provide insights into the design and synthesis of novel therapeutic agents.
Used in Agrochemical Industry:
4(3H)-Quinazolinone, 2-amino-5-chlorois used as an intermediate in the synthesis of various agrochemicals, such as pesticides and herbicides. Its potential biological activities make it a valuable component in the development of new agrochemical products.

Check Digit Verification of cas no

The CAS Registry Mumber 50440-85-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,4,4 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 50440-85:
(7*5)+(6*0)+(5*4)+(4*4)+(3*0)+(2*8)+(1*5)=92
92 % 10 = 2
So 50440-85-2 is a valid CAS Registry Number.

50440-85-2Relevant academic research and scientific papers

Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists

Pieters, Serge,McGowan, David,Herschke, Florence,Pauwels, Frederik,Stoops, Bart,Last, Stefaan,Embrechts, Werner,Scholliers, Annick,Mostmans, Wendy,Van Dijck, Kris,Van Schoubroeck, Bertrand,Thoné, Tine,De Pooter, Dorien,Fanning, Gregory,Rosauro, Mari Luz,Khamlichi, Mourad Daoubi,Houpis, Ioannis,Arnoult, Eric,Jonckers, Tim H.M.,Raboisson, Pierre

supporting information, p. 711 - 719 (2018/01/27)

The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure–activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the potent agonist 48. Pharmacokinetic and pharmacodynamic studies highlighted 48 as an orally available endogenous interferon (IFN-α) inducer in mice.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

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Paragraph 0055; 0061-0062, (2014/03/25)

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

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Page/Page column 12, (2012/12/13)

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.

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