29671-92-9

Basic information

• Product Name: CHLOROFORMAMIDINE HYDROCHLORIDE
• Synonyms: CHLOROFORMAMIDINE HYDROCHLORIDE;chloroformamidinium chloride;ChloroformamidineHCl;CARBAMIMIDIC ACID CHLORIDE HYDROCHLORIDE;Chloroformamide hydrochloride;Nsc233919;Carbamimidic chloride hydrochloride;CarbaMiMidic chloride, Monohydrochloride
• CAS NO: 29671-92-9
• Molecular Formula: CH₃ClN₂*ClH
• Molecular Weight: 114.96
• EINECS: 249-765-4
• Mol File: 29671-92-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 180°C(lit.)
• Boiling Point: 88.8°Cat760mmHg
• Flash Point: 7.5°C
• Appearance: /
• Density: 1.5592 (rough estimate)
• Vapor Pressure: 60.2mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: CHLOROFORMAMIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROFORMAMIDINE HYDROCHLORIDE(29671-92-9)
• EPA Substance Registry System: CHLOROFORMAMIDINE HYDROCHLORIDE(29671-92-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 29671-92-9(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/CH3ClN2.ClH/c2-1(3)4;/h(H3,3,4);1H

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Relevant articles and documents

The Use of Chloroformamidine Hydrochloride as a Reagent for the Synthesis of Guanidines from Electron Deficient Aromatic Amines

In efforts to optimize a manufacturing process for an internal development compound, a clean, efficient approach to guanidine synthesis using chloroformamidine hydrochloride was identified. To investigate the general utility of this methodology towards electron-deficient aromatic amines, a set of favorable conditions were developed from a series of screens, and the scope of the reaction was probed. The successful application of this chemistry to a variety of pyridines, anilines, and heterocyclic compounds highlights its use as an improved, alternative guanylation method for this often challenging set of aromatic amines.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.