29671-92-9

Usage

Chemical Properties

white powder

InChI:InChI=1/CH3ClN2.ClH/c2-1(3)4;/h(H3,3,4);1H

Upstream product

• 420-04-2 CYANAMID 
• 156-62-7 calcium cyanamide 
• 71996-43-5 Bis-(1-chloro-2,2-dimethyl-1-phenyl-propyl)-carbodiimide 
• 71996-41-3 N,N'-bis(1-chloro-2,2,2-trifluoroethyl)carbodiimide 

Downstream Products

• 37071-30-0 7-phenyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2,4-diamine 
• 37071-31-1 5-phenyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2,4-diamine 
• 42160-21-4 5-(4-chloro-phenyl)-6-methyl-thieno[2,3-d]pyrimidine-2,4-diamine 
• 42160-19-0 5-benzyl-6-methyl-thieno[2,3-d]pyrimidine-2,4-diamine 
• 18620-94-5 6-benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diamine 
• 42160-22-5 5-(4-chloro-phenyl)-6-ethyl-thieno[2,3-d]pyrimidine-2,4-diamine 
• 42160-14-5 6-(3,4-dichloro-benzyl)-5-methyl-thieno[2,3-d]pyrimidine-2,4-diamine 
• 42160-23-6 5,6-diphenyl-thieno[2,3-d]pyrimidine-2,4-diamine 
• 42160-20-3 5-benzyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diamine 
• 27018-14-0 2,4-diamino-5-methylquinazoline 
• 50440-85-2 2-amino-5-chloroquinazolin-4(3H)-one 
• 50440-82-9 2-amino-3,4-dihydro-6-methyl-4-oxoquinazoline 
• 119584-81-5 5-ethoxy-2,4-diaminoquinazoline 
• 119584-75-7 5-bromo-2,4-diaminoquinazoline 

Relevant academic research and scientific papers

The Use of Chloroformamidine Hydrochloride as a Reagent for the Synthesis of Guanidines from Electron Deficient Aromatic Amines

In efforts to optimize a manufacturing process for an internal development compound, a clean, efficient approach to guanidine synthesis using chloroformamidine hydrochloride was identified. To investigate the general utility of this methodology towards electron-deficient aromatic amines, a set of favorable conditions were developed from a series of screens, and the scope of the reaction was probed. The successful application of this chemistry to a variety of pyridines, anilines, and heterocyclic compounds highlights its use as an improved, alternative guanylation method for this often challenging set of aromatic amines.

THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to thioether derivatives (1) as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.

Ligand based design of novel histamine H4 receptor antagonists; Fragment optimization and analysis of binding kinetics

The histamine H4 receptor is a G protein-coupled receptor that has attracted much interest for its role in inflammatory and immunomodulatory functions. In our search for new H4R ligands, a low affinity isoquinoline fragment was optimized to 7-(furan-2-yl)-4-(piperazin-1-yl) quinazolin-2-amine (VUF11489), as a new H4R antagonist. Analysis of its binding kinetics at the human H4R showed this compound to have a very different dissociative half-life in comparison with reference antagonist JNJ7777120.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.

Synthesis of a novel series of thieno[3,2-d]pyrimidin-4-(3H)-ones

2-Aminothieno[3,2-d]pyrimidin-4-ones were synthesized in one step by condensation of 3-amino(benzo)thiophene car-boxylate with chloroformamidine hydrochloride. Georg Thieme Verlag Stuttgart.

QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS

Compounds that modulate the histamine H4 receptor, and which may be useful for treating or preventing disorders and conditions mediated by the histamine H4 receptor, e.g. inflammation, are of Formula (I):

TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF

The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.

PREPARATION OF 4-SUBSTITUTED 2-AMINO-BENZO[4,5]FURO [3,2-D]PYRIMIDINE DERIVATIVES

The present invention is directed to a process for the preparation of a compound of formula (I), wherein R1, R2 and X have the meaning as indicated in the description and claims. Said compounds are useful as key intermediates for the preparation of the related pharmaceutically active compounds or as active compounds.

2-AMINO PYRIDINE COMPOUNDS

The present invention is directed to 2-aminopyrimidine compounds and pharmaceutically acceptable salts thereof, their synthesis and their use as HSP-90 inhibitors.